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Aluminium-induced tangles in cultured rat neurones

Enhanced effect of aluminium by addition of maltol

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Summary

Neurofilamentous tangles have been induced in cultured neurones from rat brain hemispheres by application of both aluminium and maltol. Quantitative evaluation revealed a significantly higher percentage of tangle containing neurones when using the aluminium-maltol mixture than after application of aluminium alone. Tangles were found to be consistently stained with monoclonal antibodies to neurofilament proteins but failed to react with polyclonal antibodies against microtubule-associated proteins 1, 2 and tau.

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Authors and Affiliations

  1. Department of Neuropathology, University of Basel, Schönbeinstrasse 40, CH-4003, Basel, Switzerland

    D. Langui, A. Probst & J. Ulrich

  2. Department of Neuroscience, Institute of Psychiatry, University of London, De Crespigny Park, Denmark Hill, SE5 8AF, London, Great Britain

    B. Anderton

  3. Laboratoire d'Anatomie Pathologique et de Microscopie Electronique, Universite Libre de Bruxelles, Bruxelles, Belgium

    J. -P. Brion

Authors
  1. D. Langui
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  2. A. Probst
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  3. B. Anderton
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  4. J. -P. Brion
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  5. J. Ulrich
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Supported by Sandoz Ltd. and the Wellcome Trust

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Langui, D., Probst, A., Anderton, B. et al. Aluminium-induced tangles in cultured rat neurones. Acta Neuropathol 80, 649–655 (1990). https://doi.org/10.1007/BF00307634

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  • DOI: https://doi.org/10.1007/BF00307634

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