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Studies on liver toxicants

Mixed-function oxidase activities and hemoprotein contents in livers of rats poisoned with bromobenzene

  • Original Investigations
  • Mechanisms of Cellular Toxicity
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Abstract

In liver microsomes of rats 5 h after intraperitoneal administration of bromobenzene, the activities of a series of drug-metabolizing mixed-function oxidases, i. e., ketamine and aminopyrine N-demethylases, methylayapanine and methoxybiphenyl O-demethylases, and ethoxycoumarin O-deethylase, as well as glutathione and cytochrome b5 contents were found to be decreased, whereas the activities of microsomal, NADPH-dependent cytochrome c and neotetrazolium reductases as well as cytochrome P-450 were unchanged.

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Authors and Affiliations

  1. Hoechst AG, D-6230, Frankfurt am Main 80, Federal Republic of Germany

    Friedrich E. Beyhl & Dieter G. Mayer

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  1. Friedrich E. Beyhl
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  2. Dieter G. Mayer
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Dedicated to Professor Dr. med. Herbert Remmer on the occasion of his 65th Birthday

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Beyhl, F.E., Mayer, D.G. Studies on liver toxicants. Arch Toxicol 60, 109–111 (1987). https://doi.org/10.1007/BF00296960

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  • DOI: https://doi.org/10.1007/BF00296960

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