Abstract
The results of 203 patients who underwent firstpass radionuclide angiography (FP), as well as quantitative equilibrium radionuclide ventriculography (qERNV), were stored in a data base system and evaluated statistically. In patients with coronary artery disease (CAD) without previous myocardial infarction (MI), evaluation of global and regional ejection fraction (gEF, rEF) at rest revealed a poor sensitivity of 64% (Rest-qERNV) and 69% (Rest-FP), respectively. In patients with a history of one previous MI, the sensitivity of both methods was equivalent: FP 87% and qERNV 84%. In patients with several MIs, sensitivity was higher than 90%. Concerning localization of MI, remarkable differences between FP and qERNV were found. In posterior wall infarction, the FP sensitivity was 87% and qERNV only 67%, whereas in anterior wall infarction, the results were similar for both methods: 93% (FP) and 96% (qERNV), respectively. Since 30° RAO camera position achieves the best visualization of the anterior and posterior wall, FP is superior to qERNV in the evaluation of posterior wall asynergies. In addition, qERNV often fails to discriminate anterior and posterior wall motion abnormalities.
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Bonow RO, Bacharach StL, Green MV, Kent KM, Rosing DR, Lipson LC, Leon MB, Epstein StE (1981) Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography. Circulation 64:315–323
Breuel HP, Felix R, Knopp R, Otten H, Simon H, Winkler C (1978) Funktionszsintigraphie der Kontraktion des linken Ventrikels. III. Ergebnisse bei Patienten mit koronarer Herzerkrankung. Fortschr Roentgenstr 129:317–320
Brill G, Oberhausen E, Wilhelm H (1981) Quantitative Radiokardiographie zur Differentialdiagnose und Verlaufskontrolle von Herzkrankheiten. J Nucl Med 20:124–128
Buell U, Kirsch CM, Cyran J, Bolte HD, Luederitz B (1979) Einsatz von Einkristall-Gammakamera und Kleinrechner bei der Ersten Radionuklid-Passage zur Bestimmung von Auswurffraktion und Wandbewegungen des linken Ventrikels. Fortschr Roentgenstr. 130:27–24
Buell U, Strauer BE, Cyran J, Knesewitsch P, Kleinhans E (1980) Bestimmung globaler und regionaler Parameter der Herzfunktion mit Hilfe der Radionuklid-Kardiographie bei der ersten Passage des Radionuklids. Verh. Dtsch. Ges. Herz Kreislaufforsch 46:92–104
Buell U, Knesewitsch P, Kleinhans, Seiderer M, Strauer BE (1981) Die Erste Radionuklid-Passage mit der Einkristall-Gamma-Kamera. J Nucl Med 20:109–115
Dodge HT, Sandler H, Ballew DW, Lord JD JR (1960) The use of biplane angiocardiography for the measurement of left ventricular volume in man. Am Heart J 60:762–776
Hammermeister KE, Brooks RC, Warbasse JR (1974a) The rate of change of left ventricular volume in man. I. Validation and peak systolic ejection rate in health and disease. Circulation 49:729–738
Hammermeister KE, Warbasse JR (1974b) The rate of change of left ventricular volume in man. II. Diastolic events in health and disease. Circulation 49:739–747
Kelly MJ, Kalff V, Rose D, Harper RW, Anderson StT, Pitt A (1985) Value of combined assessment of global and segmental ventricular contraction with right anterior oblique ECG-gated first-pass and left anterior oblique equilibrium radionuclide ventriculography. Eur J Nucl Med 10:214–221
Kleinhans E, Buell U, Kirsch CM (1980) Bestimmung der Auswurffraktion des linken Ventrikels aus der ersten Indikatorbolus-Passage. J Nucl Med 19:244–249
Kleinhans E, Seiderer M, Knesewitsch P, Kirsch CM, Buell U (1983). Halbautomatische, viertelelliptische Abgrenzung des linken Ventrikels in der Ersten Radionuklid-Passage und der Aequilibrium-Ventrikulographie. 21. Internationale Jahrestagung der Europaeischen Gesellschaft für Nuklearmedizin, Ulm, Sept. 1983
Knesewitsch P, Kleinhans E, Seiderer M, Doliwa R, Buell U (1984a) Die quantitative Aequilibrium-Radionuklid-Ventrikulographic zur Beurteilung des Schweregrades einer koronaren Herzerkrankung. J Nucl Med 23:41–46
Knesewitsch P, Kleinhans E, Seiderer M, Klepzig M, Buell U (1984b) Die quantitative Ruhe-Radionuklid-Ventrikulographie zur multifaktoriellen Analyse der linksventrikulaeren Funktion. J Nucl. Med 23:163–169
Lichtlen P (1976) Koronarangiographie. Straube, Erlangen 1976
Polak JF, Kemper AJ, Bianco JA, Parisi AF, Tow DE (1982) Resting early peak diastolic filling rate: a sensitive index of myocardial dysfunction in patients with coronary artery disease. J Nucl Med 23:471–478
Seiderer M, Bohn J, Buell U, Kleinhans E, Strauer BE (1983) Influence of background and absorption correction on nuclear quantification of left ventricular end-diastolic volume. Br J Radiol 56:183–187
Seiderer M, Kleinhans E, Buell U, Strauer BE (1982) Die regionalen Auswurffraktionen zur Beurteilung der linksventrikulaeren Funktion. Fortschr Roentgenstr. 137:455–461
Slutsky RA, Gordon D, Karliner J, Battler A, Walski St, Verba J, Pfisterer M, Peterson K, Ashburn W (1979) Assessment of early ventricular systole by first pass radionuclide angiography: useful method for detection of left ventricular dysfunction at rest in patients with coronary artery disease. Am J Cardiol 44:459–465
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Knesewitsch, P., Kleinhans, E. & Buell, U. Combined evaluation of first-pass radionuclide angiography and equilibrium radionuclide ventriculography in the diagnosis of coronary artery disease. Eur J Nucl Med 12, 115–119 (1986). https://doi.org/10.1007/BF00276702
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DOI: https://doi.org/10.1007/BF00276702