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Agreement between left ventricular ejection fraction assessed in patients with gated IQ-SPECT and conventional imaging

  • Original Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The aim of the study was to assess the agreement between the left ventricular ejection fraction (LVEF) values obtained with IQ-SPECT and those obtained with a conventional gamma camera equipped with low-energy high-resolution (LEHR), considered as the method of reference.

Methods

Gated-stress MPI using 99mTc-tetrofosmin was performed in 55 consecutive patients. The patients underwent two sequential acquisitions (Method A and B) performed on Symbia-IQ SPECT with different acquisition times and one (Method C) on a Ecam SPECT equipped with LEHR collimators. The values of the different datasets were compared using the Bland-Altman analysis method: the bias and the limits of agreement (LA) were estimated in a head-to-head comparison of the three protocols.

Results

In the (Method A-Method C) comparison for LVEF, the bias was 3.8% and the LAs ranged from − 9.3% to 16.8%. The agreement was still lower between Method B and C, whilst only slightly improved when Methods A and B were compared.

Conclusions

The wide amplitude in LA intervals of about 30% indicates that IQ and LEHR GSPECT are not interchangeable. The values obtained with IQ-SPECT should only be used with caution when evaluating the functional state of the heart.

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Abbreviations

EDV:

End diastolic volume

ESV:

End systolic volume

FBP:

Filtered back projection

GSPECT:

ECG-gated SPECT

LA:

Limits of agreement

LEHR:

Low-energy-high-resolution

LV:

Left ventricular

LVEF:

Left ventricular ejection fraction

MPI:

Myocardial perfusion imaging

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Acknowledgements

We would like to thank Clizia Dionisi (MSc) for her valuable contribution in the collection of data.

Disclosures

No potential conflict of interest relevant to this article was reported.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital ‘Maggiore della Carità’, Novara, Italy

    Lucia Leva MD & Gianmauro Sacchetti MD

  2. Department of Medical Physics, University Hospital ‘Maggiore della Carità’, Novara, Italy

    Roberta Matheoud PhD & Marco Brambilla PhD

  3. Department of Radiology, University Hospital ‘Maggiore della Carità’, Novara, Italy

    Alessandro Carriero MD

Authors
  1. Lucia Leva MD
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  2. Roberta Matheoud PhD
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  3. Gianmauro Sacchetti MD
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  4. Alessandro Carriero MD
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  5. Marco Brambilla PhD
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Contributions

Study concept and design: M. Brambilla, L. Leva, R. Matheoud. Data acquisition: L. Leva, G. Sacchetti, R. Matheoud. Analysis and interpretation of data: M. Brambilla, L. Leva, R. Matheoud, A. Carriero. Drafting of the manuscript: M. Brambilla, R. Matheoud, L. Leva. Clinical revision of the manuscript for important intellectual content: L. Leva, G. Sacchetti, A. Carriero. Final approval of the manuscript submitted: all authors.

Corresponding author

Correspondence to Marco Brambilla PhD.

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Leva, L., Matheoud, R., Sacchetti, G. et al. Agreement between left ventricular ejection fraction assessed in patients with gated IQ-SPECT and conventional imaging. J. Nucl. Cardiol. 27, 1714–1724 (2020). https://doi.org/10.1007/s12350-018-1457-7

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  • DOI: https://doi.org/10.1007/s12350-018-1457-7

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