Summary
An investigation of the influences of marked chromosome sections on quantitative traits in a backcross-generation with 2321 mice (C57BL/6JHan × (AKR/NHan×C57BL/6JHan)) is described. In the animals the chromosomes 1, 4, 7, and 8 were marked by the gene loci Idh-1, Gpd-1, Gpi-1s, Es-1, resp. Within the backcross-generation, for Idh-1 and Es-1, more heterozygous genotypes were found than expected under random conditions. By comparing animal-groups with different homologous sections of the marked chromosomes, effects were observed on quantitative traits (body length and weight, dry weight and matter, fat weight and content). The results indicate that a few chromosome sections influence to a major extent the genetic variation of some quantitative traits.
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Literature
Benacerraf, B.; Germain, R.N. (1978): The immune response genes of the major histocompatibility complex. Immunol. Rev. 38, 70–119
Birdsall, D.A.; Redfield, J.; Cameron, D.A. (1970): White bands on starch gels stained for esterase activity: a new polymorphism. Biochem. Genet. 5, 655–658
Carter, N.D.; Parr, C.W. (1967): Isoenzymes of phosphoglucose isomerase in mice. Nature 216, 511
Coleman, D.L. (1978): Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141–148
DeLorenzo, R.J.; Ruddle, F.H. (1969): Genetic control of two electrophoretic variants of glucosephosphate isomerase in the mouse (Mus musculus). Biochem. Genet. 3, 151–162
Eslami-Matin, F.; Christen, U.; Bartels, H. (1974): Vergleichende Überprüfung von Methoden zur Fettbestimmung bei Fleischerzeugnissen. Fleischwirtschaft 54, 1975–1978; 1981–1984
Fox, D.J.; Crockett, R.V. (1977): Characterization of mitochondrial NADP-dependent isocitrate dehydrogenase from normal and genetically obese (ob/ob) mice. Biochem. Med. 18, 192–205
Geldermann, H. (1975): Investigations on inheritance of quantitative characters in animals by gene markers. Theor. Appl. Genet. 46, 319–330
Henderson, N.S. (1965): Isozymes of isocitrate dehydrogenase: subunit structure and intracellular location. J. Exp. Zool. 158, 263–274
Kluge, R. (1980): Beziehungen zwischen markierten Chromosomenabschnitten und quantitativen Merkmalen bei der Labormaus. PhD. Thesis, Göttingen
Kluge, R.; Rapp, K.G.; Geldermann, H.: Meßwerte quantitativer Merkmale bei AKR/NHan und C57BL/6JHan Mäusen und deren Kreuzungsnachkommen. Z. Versuchstierkd. (submitted)
Montag, A. (1973): Zur densitometrischen Fettbestimmung in milcheiweißreichen Erzeugnissen mit dem FOSS-LET-Gerät. Dtsch. Lebensmittelrundsch. 69, 470–472
Rendel, J.M. (1979): Canalisation and selection. In: Quantitative Genetic Variation (ed. Tompson, J.N.; Thoday, J.M.), pp. 139–156. New York, San Francisco, London: Acad. Press
Ruddle, F.H.; Shows, T.B.; Roderick, T.H. (1968): Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus). Genetics 58, 599–606
Shaw, C.R.; Prasad, R. (1970): Starch gel electrophoresis of enzymes, a compilation of recipes. Biochem. Genet. 4, 297–320
Shows, T.B.; Tashian, R.E.; Brewer, G.J. (1964): Erythrocyte glucose-6-phosphate dehydrogenase in caucasians: new inherited variant. Science 145, 1056–1057
Staats, J. (1976): Standardized nomenclature for inbred strains of mice: sixth listing. Cancer Res. 36, 4333–4377
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Communicated by H. Abplanalp
This investigation was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 146)
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Kluge, R., Geldermann, H. Effects of marked chromosome sections on quantitative traits in the mouse. Theoret. Appl. Genetics 62, 1–4 (1982). https://doi.org/10.1007/BF00276270
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DOI: https://doi.org/10.1007/BF00276270