Skip to main content
SpringerLink
Log in

Reduction of physical assignments to a standard lod table: Chromosome 1

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

A method for reducing physical assignments of markers to a lod score table is described, and these tables are added to those from family data to provide a consistent genetic map of chromosome 1. Various chiasma maps are considered, and the results suggest that terminalization of chiasmata does occur. Chiasmata appear to be significantly less localized in oocytes than spermatocytes, and crossing-over in the vicinity of the centromere is more common in females than in males.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Benn PA, Shows TB, D'Ancona GG, Croce CM, Orkwiszewski KG, Mellman WJ (1979) Assignment of a gene for uridine diphosphate galactose-4-epimerase to human chromosome 1 by somatic cell hybridization, with evidence for a regional assignment to 1pter→1p21. Cytogenet Cell Genet 24:138–142

    Article  CAS  Google Scholar 

  • Burgerhout WG (1978) A standard procedure for gene assignment by use of somatic cell hybrids. Human Gene Mapping 4 (1977): Fourth International Workshop of Human Gene Mapping. Birth Defects 14:4. Cytogenet Cell Genet 22: 689–693

    Google Scholar 

  • Carter TC, Falconer DS (1951) Stocks for detecting linkage in the mouse and the theory of their design. J Genet 50:307–323

    Article  CAS  Google Scholar 

  • Fennell SJ, Malcolm S, Williamson R, Ferguson-Smith MA (1979) Use of chromosomal translocations with in situ DNA hybridization to confirm localisation of human 5S ribosomal RNA genes. J Med Genet 16:246–253

    Article  CAS  Google Scholar 

  • Haldane JBS (1919) The combination of linkage values, and the calculation of distance between the loci of linked factors. J Genet 8:293–303

    Article  Google Scholar 

  • Hultén M (1974) chiasma distribution at diakinesis in the normal human male. Hereditas 76:55–78

    Article  Google Scholar 

  • Human Gene Mapping 5 (1979) Fifth International Workshop on Human Gene Mapping. Birth Defects 15: 11. Cytogenet Cell Genet 25: 1–4

  • Keats BJB, Morton NE, Rao DC, Williams WR (1979) A source book for linkage in man. Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Koch GA, Brown JA, Shows TB (1978) Gene assignment of α-fucosidase and glucose dehydrogenase to the p21→pter region of chromosome 1 in man. Somat Cell Genet 4:313–322

    Article  CAS  Google Scholar 

  • Kosambi DD (1944) The estimation of map distances from recombination values. Ann Eugen 12:172–175

    Article  Google Scholar 

  • Lin MS, Oizumi J, Ng WG, Alfi OS, Donnell GN (1979a) Assignment of the gene for uridine diphosphate galactose-4-epimerase to human chromosome 1 by human-mouse somatic cell hybridization. Somat Cell Genet 5:363–371

    Article  CAS  Google Scholar 

  • Lin MS, Oizumi J, Ng WG, Alfi OS, Donnell GN (1979b) Regional mapping of the gene for human UDPGal 4-epimerase on chromosome 1 in mouse-human hybrids. Cytogenet Cell Genet 24:217–223

    Article  CAS  Google Scholar 

  • Morton NE (1956) The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Am J Hum Genet 8:80–96

    CAS  PubMed  PubMed Central  Google Scholar 

  • Morton NE (1978) Analysis of crossing-over in man. Human Gene Mapping 4 (1977): Fourth International Workshop on Human Gene Mapping. Birth Defects 14:4. Cytogenet Cell Genet 22: 15–36

    Google Scholar 

  • Morton NE, Rao DC, Lindsten J, Hultén M, Yee S (1977) A chiasma map of man. Hum Hered 27:38–51

    Article  CAS  Google Scholar 

  • Morton NE, Rao DC, Yee S (1976) An inferred chiasma map of Drosophila melanogaster. Heredity 37:405–411

    Article  CAS  Google Scholar 

  • Noades JE, Corney G, Cook PJL, Putt W, King J, Fisher RA, Spowart G, Lee M, Bowell PJ (1979) The Scianna blood group lies distal to uridine monophosphate kinase on chromosome 1p. Ann Hum Genet 43:121–132

    Article  CAS  Google Scholar 

  • Paul TD, Brandt IK, Elsas LJ, Jackson CE, Nance CS, Nance WE (1979) Linkage analysis using heterozygote detection in phenylketonuria. Clin Genet 16:217–232

    Article  CAS  Google Scholar 

  • Rao DC, Keats BJB, Lalouel JM, Morton NE, Yee S (1979) A maximum likelihood map of chromosome 1. Am J Hum Genet 31:680–696

    CAS  PubMed  PubMed Central  Google Scholar 

  • Rao DC, Morton NE, Lindsten J, Hultén M, Yee S (1977) A mapping function for man. Hum Hered 27:99–104

    Article  CAS  Google Scholar 

  • Rao DC, Morton NE, Lindsten J, Hultén M, Yee S (1977) A mapping function of man. Hum Hered 27:99–104

    Article  CAS  Google Scholar 

  • Williams WR, Morton NE, Lew R, Yee S (1979) The likely region of overlap (LRO) method for physical assignment of loci. Hum Genet 47:297–304

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. D. C. Rao

    Present address: Dept. of Psychiatry, Washington University, 4566 Scott Avenue, Box 8067, 63110, St. Louis, MO, USA

Authors and Affiliations

  1. Population Genetics Laboratory, University of Hawaii, 1980 East West Road, 96822, Honolulu, HI, USA

    B. J. B. Keats

  2. Division of Biostatistics, Dept. of Preventive Medicine, Washington University, 4566 Scott Avenue, Box 8067, 63110, St. Louis, MO, USA

    D. C. Rao

  3. Dept. of Genetics, Washington University, 4566 Scott Avenue, Box 8067, 63110, St. Louis, MO, USA

    N. E. Morton

Authors
  1. B. J. B. Keats
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. E. Morton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. C. Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by Grants GM 23021, GM 24941, and NF 1-475 from the U.S. National Institutes of Health and National Foundation, PGL Paper No. 228

Rights and permissions

Reprints and permissions

About this article

Cite this article

Keats, B.J.B., Morton, N.E. & Rao, D.C. Reduction of physical assignments to a standard lod table: Chromosome 1. Hum Genet 56, 353–359 (1981). https://doi.org/10.1007/BF00274692

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00274692

Keywords

Search

Navigation