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The involvement of methionine regulatory mutants in the suppression of B12-dependent homocysteine transmethylase (metH) mutants of Salmonella typhimurium

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Summary

Certain metH mutants (which lack the B12-dependent homocysteine transmethylase) give rise to revertants resistant to the methionine analogue, ethionine. The revertants retain the original metH mutation and its suppression is due to two mutations, supI and supII. The supI mutation, which confers ethionine resistance, appears to be a mutation in the methionine regulatory gene, metJ, but the location and nature of supII have not been determined. It is possible that suppression results from a direct association between the metH and metJ gene products or by the introduction of an alternative pathway of homocysteine methylation.

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Authors and Affiliations

  1. Genetics Department, Birmingham University, Birmingham, England

    Julie M. Whitehouse & Derek A. Smith

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  1. Julie M. Whitehouse
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  2. Derek A. Smith
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Communicated by H. Böhme

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Whitehouse, J.M., Smith, D.A. The involvement of methionine regulatory mutants in the suppression of B12-dependent homocysteine transmethylase (metH) mutants of Salmonella typhimurium . Molec. Gen. Genet. 129, 259–267 (1974). https://doi.org/10.1007/BF00267918

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  • DOI: https://doi.org/10.1007/BF00267918

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