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Le controle du développement des bactériophages tempérés

IV. Action spécifique du produit N au niveau d'une barrière de transcription

Control of development in temperate bacteriophages

IV. Specific action of N product at a transcription stop signal

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Summary

Viable recombinants having the (N-im) region of ϕ80 and the (P-R) region of λ can be isolated from crosses between ϕ80 and λ, but only if the λ parent carries a byp mutation.

It is suggested that the transcriptional terminator t R 2located between genes P and Q can be bypassed only in the presence of Nλ product and not in the presence of N ϕ80 product.

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Bibliographie

  • Appleyard, R.: Segregation of lysogenicity during bacterial recombination in E. coli K12. Genetics 39, 429 (1954).

    Google Scholar 

  • Beckman, J. S., Daniel, V., Tichaner, Y., Littauer, V. Z.: Binding of the termination factor ϱ to DNA. Biochem. biophys. Res. Commun. 43, 806 (1971).

    Google Scholar 

  • Butler, B., Echols, H.: Regulation of bacteriophage λ development by gene N; Properties of a mutation that bypasses N control of late proteins synthesis. Virology 40, 212 (1970).

    Google Scholar 

  • Campbell, A.: Sensitive mutants of bacteriophage λ. Virology 14, 22 (1961).

    Google Scholar 

  • Couturier, M., Dambly, C.: Activation séquentielle des fonctions tardives chez les bacteriophages tempérés. C.R. Acad. Sci. (Paris) 270, 428 (1970).

    Google Scholar 

  • Dambly, C., Couturier, M., Thomas, R.: Control of development in temperate bacteriophages. II. Control of lysozyme synthesis. J. molec. Biol. 32, 67 (1968).

    Google Scholar 

  • Fiendt, M., Hradecna, Z., Lozerjn, H., Szybalski, W.: Electron micrographic mapping of deletions, substitions, inversions and homologies in the λ and ϕ80 genomes. The bacteriophage λ, A.D. Hershey, ed. Cold Spring Harbor: 1971.

  • Franklin, N.: The N. operon of λ: extent and regulation as observed in fusions to the tryptophan operon of E. coli. The bacteriophage λ, A.D. Hershey, ed. Cold Spring Harbor: 1971.

  • Georgopoulos, C., Herskowitz, I.: Escherichia coli mutants blocked in λ DNA synthesis. The bacteriophage λ, A.D. Hershey, ed. Cold Spring Harbor: 1971.

  • Ghysen, A., Pironio, M.: Relationship between the N function of bacteriophage λ and host RNA polymerase. Sous presse J. molec. Biol.

  • Gottesman, M., Yarmolinsky, M.: Integration-negative mutants of bacteriophage. J. molec. Biol. 31, 487 (1968).

    Google Scholar 

  • Hopkins, N.: Bypassing a positive regulator: isolation of a λ mutant that does not require N product to grow. Virology 40, 223–229 (1970).

    Google Scholar 

  • Luzzati, D.: Regulation of λ exonuclease synthesis: Role of the N gene product and λ repressor. J. molec. Biol. 49, 515 (1970).

    Google Scholar 

  • Pereira Da Silva, L., Jacob, F.: Etude génétique d'une mutation modifiant la sensibilité à l'immunité chez le bacteriophage λ. Ann. Inst. Pasteur 115, 145 (1968).

    Google Scholar 

  • Roberts, J.: Termination factor for RNA synthesis. Nature (Lond.) 224, 1168 (1969).

    Google Scholar 

  • —: The ϱ factor: Termination and anti-termination in λ. Cold Spr. Harb. Symp. quant. Biol. 35, 121 (1970).

    Google Scholar 

  • Sato, K.: Genetic map of bacteriophage ϕ80: Genes of the right arm. Virology 40, 1067 (1970).

    Google Scholar 

  • —, Nishimune, Y., Sato, M., Numich, R., Matsushiro, A., Inokuchi, H., Ozeki, H.: Suppressor-sensitive mutants of coliphage ϕ80. Virology 34, 1637 (1968).

    Google Scholar 

  • Szpirer, J., Brachet, P.: Relations physiologiques entre les phages tempérés λ et ϕ80. Molec. gen. Genet. 108, 78 (1970).

    Google Scholar 

  • —, Thomas, R., Radding, C.: Hybrids of bacteriophages λ and ϕ80: a study of non vegetative functions. Viorology 37, 585 (1969).

    Google Scholar 

  • Thomas, R.: Control of development in temperate bacteriophages. I. Induction of prophages genes following hetero-immune super-infection. J. molec. Biol. 22, 79–95 (1966).

    Google Scholar 

  • —: Control of development in temperate bacteriophages. II. Which prophage genes are and which are not trans-activable in the presence of immunity. J. molec. Biol. 49, 393–404 (1970).

    Google Scholar 

  • —: Regulation of gene expression in bacteriophage λ. Curr. Top. Microbiol. 56, 13–42 (1971).

    Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Génétique, Faculté des Sciences, Université Libre de Bruxelles, Belgique

    Josiane Szpirer

  2. Department of Biochemistry Microbiology Unit, University of Oxford, South Parks Road, Oxford, Great Britain

    Josiane Szpirer

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  1. Josiane Szpirer
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Additional information

Communicated by W. Arber

Les numéros I, II et III de cette série sont respectivement Thomas, 1966. Dambly, Couturier et Thomas, 1968. Thomas, 1970.

Chargé de Recherches au Fonds National de la Recherche Scientifique Belge.

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Szpirer, J. Le controle du développement des bactériophages tempérés. Molec. Gen. Genet. 114, 297–304 (1972). https://doi.org/10.1007/BF00267498

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  • DOI: https://doi.org/10.1007/BF00267498

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