Skip to main content
SpringerLink
Log in

Untersuchungen über eine zentralnervöse Regulation des Natriumhaushaltes

  • Published:
Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie Aims and scope Submit manuscript

Summary

Experiments have been performed to try the release of Vasopressin by electrical stimulation within the diencephalon of rats during oral infusion of destilled water or isotonic saline solution.

After an oral load of destilled water electrical stimulation resulted in an antidiuresis and in an increase in urinary sodium concentration. Histological examination of these rat-brains have shown that the points of the electrodes located in the diencephalon were in close topographical correlation with arteries which are accompanied by ganglion cells.

In the beginning of the experiments with isotonic saline solution there was a retention of sodium which exceeded the retention of water. Under these conditions electrical stimulation resulted in an increase of urinary sodium concentration and output.

The results allow the conclusion that Vasopressin adjusts the increased osmolarity which occurs after primary sodium retention also by augmenting sodium excretion and not by reducing water output only.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Abrahams, V. C., and M. Pickford: Simultaneous Observations of the Rate of Urine Flow and Spontaneous Uterine Movements in the Dog, and their Relationship to posterior Lobe Activity. J. Physiol. (Lond.) 126, 329 (1954).

    Google Scholar 

  • Brooks, F. P., and M. Pickford: The Effect of posterior pituitary Hormones on the Excretion of Electrolytes in Dogs. J. Physiol. (Lond.) 142, 468 (1958).

    Google Scholar 

  • Brunner, H., G. Kuschinsky u. G. Peters: Die Wirkung von Vasopressin auf die renale Wasser- und Salzausscheidung der Ratte bei Veränderungen der Salzkonzentration des Trinkwassers und nach Nierenparenchymresektionen. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 228, 434 (1956).

    Google Scholar 

  • Brunner, H., G. Kuschinsky u. G. Peters: Der Einfluß von Oxytocin auf die renale Wasser- und Salzausscheidung der Ratte. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 228, 457 (1956a).

    Google Scholar 

  • Dyke, H. B. van, K. Adamsons and S. L. Euger: Aspects of the Biochemistry and Physiology of the Neurohypophyseal Hormones. Recent Progr. Hormone Res. 11, 1 (1955).

    Google Scholar 

  • Harris, G. W.: The Excretion of an antidiuretic Substance by the Kidney, after electrical Stimulation of the Neurohypophysis in the unaesthetized Rabbit. J. Physiol. (Lond.) 107, 430 (1948).

    Google Scholar 

  • Herken, H.: Die Rolle des Vasopressins in der Pathogenese des Ödems. Dtsch. med. Wschr. 1957, 2177.

  • Herken, H.: Neue Untersuchungen über die hormonalen Ursachen des Ödems. Wien. klin. Wschr. 1958, 518.

  • Herken, H.: Kritische Bemerkungen zur postoperativen Infusion von Elektrolytlösungen. Langenbecks Arch. klin. Chir. 292, 90 (1959).

    Google Scholar 

  • Herken, H.: Die Regulation der gestörten Diurese durch Pharmaka. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 238, 158 (1960).

    Google Scholar 

  • Herken, H., G. Senft u. J. Schaper: Die Beteiligung des Vasopressins an der Entstehung des Ödems. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 230, 284 (1957).

    Google Scholar 

  • Herken, H., J. Natzschka u. G. Senft: Die Wirkung elektrischer Reizungen im Zwischenhirn auf den Salz- und Wasserhaushalt. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 234, 185 (1958).

    Google Scholar 

  • Herken, H., G. Senft u. H. Wilutzky: Die Erzeugung von Natrium- und Wasserretentionen zur Prüfung der Diuretica. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 229, 123 (1956).

    Google Scholar 

  • Hild, W., u. G. Zetler: Vergleichende Untersuchungen über das Vorkommen des Hypophysenhinterlappenhormones im Zwischenhirn einiger Säugetiere. Dtsch. Z. Nervenheilk. 167, 103 (1952).

    Google Scholar 

  • Hild, W., u. G. Zetler: Experimenteller Beweis für die Entstehung der sogenannten Hypophysenhinterlappenwirkstoffe im Hypothalamus. Pflügers Arch. ges. Physiol. 257, 169 (1953).

    Google Scholar 

  • Jewell, P. A., and E. B. Verney: An Experimental Attempt to determine the Site of the Neurohypophysial Osmoreceptor in the Dog. Phil. Trans. B 240, 197 (1957).

    Google Scholar 

  • Natzschka, J., u. G. Senft: Der Einfluß von Corticosteroiden auf die Vasopressinwirkung. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 237, 334 (1959).

    Google Scholar 

  • O'Connor, W. J., and E. B. Verney: Quart. J. exp. Physiol. 31, 393 (1942); zit. nach E. B. Verney: Osmoregulation und antidiuretisches Hormon. Ärztl. Wschr. 13, 1010 (1958).

    Google Scholar 

  • Rydin, H., and E. B. Verney: Quart. J. exp. Physiol. 27, 343 (1938); zit. nach E. B. Verney: Osmoregulation und antidiuretisches Hormon. Ärztl. Wschr. 13, 1010 (1958).

    Google Scholar 

  • Sellwood, R. V., and E. B. Verney: Phil. Trans. B 238, 361 (1955); zit. nach E. B. Verney: Osmoregulation und antidiuretisches Hormon. Ärztl. Wschr. 13, 1010 (1958).

    Google Scholar 

  • Senft, G., u. J. Natzschka: Der Einfluß eines Kaliumdefizits auf die antidiuretische Wirkung von Vasopressin. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 237, 344 (1959).

    Google Scholar 

  • Spengler, J., u. P. Huber: Topographische Beziehungen zwischen neurosekretorischen Ganglienzellen und arteriellen Gefäßen im Rattenhypothalamus. Pflügers Arch. ges. Physiol. 269, 31 (1959).

    Google Scholar 

  • Verney, E. B.: The Secretion of Pituitrin in Mammals, as shown by Perfusion of the isolated Kidney of the Dog. Proc. roy Soc. B 99, 487 (1926).

    Google Scholar 

  • Verney, E. B.: Polyuria. 1. Polyuria associated with pituitary Dysfunction. Lancet I, 216, 539 (1929).

    Google Scholar 

  • Vogt, M.: Vasopressor, Autidiuretic, and Oxytocic Activities of Extracts of the Dog's Hypothalamus. Brit. J. Pharmacol. 8, 193 (1953).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Freien Universität Berlin, Germany

    H. Herken, G. Senft & J. Natzschka

Authors
  1. H. Herken
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Senft
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Natzschka
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Herrn Professor Dr. O. Schaumann zum 70. Geburtstag gewidmet.

Mit 3 Textabbildungen

Rights and permissions

Reprints and permissions

About this article

Cite this article

Herken, H., Senft, G. & Natzschka, J. Untersuchungen über eine zentralnervöse Regulation des Natriumhaushaltes. Naunyn - Schmiedebergs Arch 240, 483–494 (1961). https://doi.org/10.1007/BF00260269

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00260269

Search

Navigation