Abstract
The effects of vertebrate neurohypophysial nonapeptides (vasopressin, vasotocin and their synthesized analogs) on urinary magnesium excretion were studied in rats. Neurohypophysial hormones and their analogs at doses stimulating V2-receptors (0.0001–0.001 nmol/100 g BM) exerted antidiuretic effect and reduced urinary magnesium excretion. At higher doses, activating V2 and V1a-receptors (0.025–0.1 nmol/100 g BW), vasotocin and its analogs (deamino-vasotocin (dAVT), deamino-Thr4-vasotocin, deamino-hArg8-vasotocin, deamino-monocarbo-vasotocin) enhanced excretion of magnesium and sodium ions. A direct relationship was revealed between the enhanced renal excretion of sodium and magnesium ions under these conditions. After the V1a-receptor antagonist injection, dAVT caused a 10-fold lower increase in magnesium excretion. The V2-receptor antagonist did not affect dAVT-induced magniuresis. The data obtained suggest that V-receptors are involved in magnesium transport regulation in the rat kidney.
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Original Russian Text © A.V. Kutina, T.A. Karavashkina, D.V. Holasava, Yu.V. Natochin, 2014, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2014, Vol. 50, No. 6, pp. 435–439.
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Kutina, A.V., Karavashkina, T.A., Holasava, D.V. et al. The effects of neurohypophysial nonapeptides and their analogs on magnesium excretion in rat kidney. J Evol Biochem Phys 50, 500–505 (2014). https://doi.org/10.1134/S0022093014060040
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DOI: https://doi.org/10.1134/S0022093014060040