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Correlation between Urinary Excretion of Arginine-Vasopressin and Renal Reabsorption of Sodium and Water

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We developed an approach for quantitative assay of injected vasopressin in urine samples by ELISA under conditions of physiological suppression of hormone secretion from the neurohypophysis into the blood. In experiments on unanesthetized rats, water load (5 ml/100 g body weight) almost completely blocked secretion of arginine-vasopressin. Injection of arginine-vasopressin in a dose of 0.1 nmol/100 g body weight after water load enhanced reabsorption of solute-free water and renal excretion of Na+, K+, and Mg2+ by 13.3, 5.5, and 5.0 times, respectively; urinary excretion of Ca2+ remained unchanged. It was found that urinary excretion of arginine-vasopressin directly correlated with reabsorption of solute-free water and renal sodium excretion.

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Authors and Affiliations

  1. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    E. I. Shakhmatova, D. V. Golosova & Yu. V. Natochin

Authors
  1. E. I. Shakhmatova
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  2. D. V. Golosova
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  3. Yu. V. Natochin
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Correspondence to Yu. V. Natochin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 10, pp. 400-403, October, 2018

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Shakhmatova, E.I., Golosova, D.V. & Natochin, Y.V. Correlation between Urinary Excretion of Arginine-Vasopressin and Renal Reabsorption of Sodium and Water. Bull Exp Biol Med 166, 417–420 (2019). https://doi.org/10.1007/s10517-019-04363-w

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  • DOI: https://doi.org/10.1007/s10517-019-04363-w

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