Abstract
A new radiotracer, 99mTc-imidodiphosphate, has been investigated in a series of 101 consecutive admissions to a Coronary Care Unit in a large teaching hospital to assess its potential as an acute myocardial infarct imaging agent. This agent shows high sensitivity for transmural infarction (0.96), subendocardial infarction (0.88) and high overall specificity (1.00). The clarity of the images produced, and the time after the acute episode when studies were positive suggest that it is the agent of choice for imaging the acutely infarcted myocardium.
Similar content being viewed by others
References
Bonte FJ, Parkey RW, Graham KD, Moore J, Stokely EM (1974) A new method formadionuclide imaging of myocardial infarcts. Radiology 110:473–474
Bonte FJ, Parkey RW, Graham KD, Moore JG (1975) Distribution of several agents useful in imaging myocardial infarcts. JNM 16:132–135
Brody KR, Hosain P, Spencer RP, Hosain F, Wagner HN Jr (1976) Technetium-99m labelled imidodiphosphate: an improved bone scanning radiopharmaceutical. Br J Radiol 49:267–269
Cowley MJ, Mantle JA, Rogers WJ, Russell RO Jr, Rackley CE, Logic JR (1977) Technetium-99m stannous pyrophosphate myocardial scintigraphy. Reliability and limitations in assessment of acute myocardial infarction. Circulation 56:192–198
Ennis JT, Walsh MJ, Mahon JM (1975) Value of infarct-specific isotope (99mTc-labelled stannous pyrophosphate) in myocardial scanning. Br Med J 3:517–520
Holman BL, Dewanjee MK, Idoine J, Fliegel CP, Davis MA, Trevis S, Eldh P (1973) Detection and localization of experimental myocardial infarction with 99mTc-tetracycline. JNM 14:595–599
Holman BL, Tanaka TT, Lesch M (1976) Evaluation of radiopharmaceuticals for the detection of acute myocardial infarction in man. Radiology 121:427–430
Holman BL, Chisholm RJ, Braunwald E (1978) The prognostic implications of acute myocardial infarct scintigraphy with 99mTc-pyrophosphate. Circulation 57:320–326
Joseph SP, Ell PJ, Ross P, Donaldson R, Elliott AT, Brown NJG, Williams ES (1978) 99mTc-imidodiphosphonate: a superior radiopharmaceutical for in vivo positive myocardial infarct imaging. II. Clinical data. Br Heart J 40:234–241
Karunaratne HB, Walsh WF, Fill HR, Resnekov L, Harper PV (1976) Technetium-99m pyrophosphate myocardial scintigraphy in patients with chest pain-lack of diagnostic specificity. JNM 17:523–524
Kerr GD, Pitt A, Wong CCL, Dugdale LM, Anderson ST (1977) Imaging of acute myocardial infarction using technetium-99m labelled phosphate compounds. Aust NZ J Med 7:1–7
Parkey RW, Bonte FJ, Stokely EM, Meyer AL, Willerson JT (1975) Analysis of Tc-99m stannous pyrophosphate myocardial scintigrams in 242 patients. JNM 16:556 (Abstr)
Walsh WF, Karunaratne HB, Resnekov L, Fill HR, Harper PV (1977) Assessment of diagnostic value of technetium-99m pyrophosphate myocardial scintigraphy in 80 patients with possible acute myocardial infarction. Br Heart J 39:974–981
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cook, D.J., Mahar, L.J., Chatterton, B.E. et al. 99mTc-imidodiphosphate — A better tracer for infarct-avid imaging. Eur J Nucl Med 7, 207–210 (1982). https://doi.org/10.1007/BF00256465
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00256465