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Stimulation of the coronary collateral circulation by lidoflazine (R 7904)

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Summary

Lidoflazine, a new and very longacting coronary vasodilator was given to 18 dogs with a chronically developing stenosis and occlusion of the circumflex coronary artery for 4 and 6 weeks respectively. 18 other dogs with chronically developing stenoses leading to occlusion of the circumflex artery were used as controls. Lidoflazine in a dosis of 20 mg/kg/day increased the speed of development of the collateral circulation and prohibited symptoms of permanent cardiac hypoxia. Permanent myocardial hypoxia, caused by a higher degree of physical activity in a group of “freely exercising” dogs produced the same favorable effects on the canine coronary collateral circulation.

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References

  1. Litvak, J., L. E. Siderides, and A. M. Vineberg: The experimental production of coronary artery insufficiency and occlusion. Amer. Heart J. 53, 505 (1957).

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  2. Schaper, W. K. A., A. H. M. Jageneau, and J. M. Bogaard: Hemodynamic and respiratory responses to dehydrobenzperidol, a potent neuroleptic compound in intact anesthetized dogs. Drug Res. 13, 316 (1963).

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  3. -- -- and solR. Xhonneux: The pharmacology of lidoflazine (R 7904), a new longacting coronary vasodilator. (In preparation.)

  4. Wetterer, E., u. H. P. Pieper: Über die Gesamtelastizität des arteriellen Windkessels und ein experimentelles Verfahren zu ihrer Bestimmung am lebenden Tier. Z. Biol. 106, 23 (1953).

    Google Scholar 

  5. Yelnosky, J., and J. F. Gardocki: A study of some of the pharmacological actions of fentanyl citrate and droperidol. Toxicol. appl. Pharmacol. 6, 63 (1964).

    Google Scholar 

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Authors and Affiliations

  1. Janssen Pharmaceutica N. V., Research Laboratoria, Beerse, Belgium

    Wolfgang K. A. Schaper, Raymond Xhonneux & Anton H. M. Jageneau

Authors
  1. Wolfgang K. A. Schaper
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  2. Raymond Xhonneux
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  3. Anton H. M. Jageneau
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With 6 Figures in the Text

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Schaper, W.K.A., Xhonneux, R. & Jageneau, A.H.M. Stimulation of the coronary collateral circulation by lidoflazine (R 7904). Naunyn - Schmiedebergs Arch 252, 1–8 (1965). https://doi.org/10.1007/BF00246424

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  • DOI: https://doi.org/10.1007/BF00246424

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