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Peracute Myocardial Infarction: Features of the Influence of α2-Adrenoreceptor Stimulation on the Isolated Heart

  • GENERAL PATHOLOGY AND PATHOLOGICAL PHYSIOLOGYGENERAL PHYSIOLOGY
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We performed a comparative analysis of the effect of α2-adrenoreceptor stimulation on the performance of Langendorff-isolated heart from rats with experimental myocardial infarction in the acute stage and sham-operated animals (control). In animals with peracute myocardial infarction, different agonist concentrations (clonidine, 10-6 and 10-9 M) produced a multidirectional effect on the left-ventricular developed pressure and speed and time parameters of heart contractility. In control rats, both concentrations of the agonist added to the perfused solution reduced contraction force. Clonidine in a concentration of 10-6 M reduced HR in both groups and in a concentration of 10-9 M, it decreased HR in control rats and caused multidirectional changes in rats with myocardial infarction. The coronary flow decreased in all series of experiments.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia

    A. M. Kuptsova, R. K. Bugrov, N. I. Ziyatdinova & T. L. Zefirov

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  1. A. M. Kuptsova
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  2. R. K. Bugrov
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  3. N. I. Ziyatdinova
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  4. T. L. Zefirov
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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 9, pp. 292-298, September, 2023

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Kuptsova, A.M., Bugrov, R.K., Ziyatdinova, N.I. et al. Peracute Myocardial Infarction: Features of the Influence of α2-Adrenoreceptor Stimulation on the Isolated Heart. Bull Exp Biol Med 176, 315–320 (2024). https://doi.org/10.1007/s10517-024-06015-0

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  • DOI: https://doi.org/10.1007/s10517-024-06015-0

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