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Nervous influences on the pulmonary circulation

Increased intracranial pressure, veratridine and bretylium

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Summary

The intravenous injection of veratridine in anesthetized dogs caused a reflex vasoconstriction of the perfused lung. A similar vasoconstriction could be elicited by increased intracranial pressure. The vasoconstriction was dependent on thoracic (T1 to T4) sympathetic ganglia.

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Authors and Affiliations

  1. From the Department of Pharmacology, Schools of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

    Domingo M. Aviado

Authors
  1. Domingo M. Aviado
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Additional information

Dedicated to Professor Dr. A. Jarisch on the occasion of his 70th birthday.

With 1 Figure in the Text

The experiments reported herein were supported by the U.S. Army Medical Research and Development Command under Contract DA-49-193-MD-2093 and by Burrougs Wellcome & Co., Inc. (U.S.A.).

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Aviado, D.M. Nervous influences on the pulmonary circulation. Naunyn-Schmiedebergs Arch 240, 446–452 (1961). https://doi.org/10.1007/BF00244937

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  • DOI: https://doi.org/10.1007/BF00244937

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