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Zuckergehalt und Wirksamkeit der Digitoxigenin- und Digoxigenindigitoxoside

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Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie Aims and scope Submit manuscript

Summary

1. At aequimolar amounts the mono-, bis- and tri-digitoxosides of Digitoxigenine are of the same potency when infused intravenously at different rates in guinea-pigs and cats.

2. Digoxigenine-mono- and -bis-digitoxoside are as active as Digoxine at short infusion-rates in guinea-pigs. However in long-lasting infusions the lethal Dose of Digoxine increases significantly while the lethal Doses of Digoxigenine-mono- and -bis-digitoxoside remain unchanged under the same conditions.

3. The bearing of these results on the relationship between sugars and activity of cardiac glycosides and some metabolic aspects are discussed.

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Authors and Affiliations

  1. Aus dem Pharmakologischen Laboratorium der C.F. Boehringer & Soehne GmbH, Mannheim-Waldhof

    G. Kroneberg

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  1. G. Kroneberg
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Herrn Professor Dr. W. S. Loewe, Salt Lake City, zum 75. Geburtstag gewidmet.

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Kroneberg, G. Zuckergehalt und Wirksamkeit der Digitoxigenin- und Digoxigenindigitoxoside. Naunyn - Schmiedebergs Arch 237, 222–228 (1959). https://doi.org/10.1007/BF00244730

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  • DOI: https://doi.org/10.1007/BF00244730

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