Summary
The distribution of gastrin immunoreactivity in the rat gut was examined by immunochemical and immunohistochemical techniques. Gastrin occurs predominantly in the antrum proper, but gastrin is found also in the adjacent part of the oxyntic mucosa and in the duodenum. In the remainder of the gut the gastrin concentration is very low. No gastrin cells and very low gastrin concentrations are observed in the antrum at birth. The gastrin concentration as well as the number of gastrin cells increases progressively with age. The antral gastrin concentration reaches adult or near-adult values 30–40 days after birth.
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This study was supported by the Swedish Medical Research Council (04 X-1007), by Riksföreningen mot Cancer (660-0 IX), Landsforeningen till Kraeftens Bekampelse, Danish Medical Research Council (512-6) and Fonden for Storkobenhavn, Faeroerne og Gronland.
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Larsson, L.I., Håkanson, R., Rehfeld, J.F. et al. Occurrence and neonatal development of gastrin immunoreactivity in the digestive tract of the rat. Cell Tissue Res. 149, 275–281 (1974). https://doi.org/10.1007/BF00222279
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DOI: https://doi.org/10.1007/BF00222279