Summary
Immuno-histochemical investigations on the brain of the rat showed: (1) the presence of neurophysins in the whole magnocellular neurosecretory hypothalamo-hypophysial system, the extra-hypothalamic neurosecretory tracts included; (2) the presence, in the external region of the median eminence, of neurophysin-like substance-containing nerve fibres which accumulate around the blood-capillaries and of which the number of detectable fibres is strongly influenced by adrenalectomy and by colchicine treatment; (3) that the suprachiasmatic nuclei produce neurophysin-like substances, the amount of which is also influenced by adrenalectomy and by colchicine treatment.
The observations strongly suggested that the neurophysin-like substance-containing nerve fibres of the external region of the median eminence of the rat are identical with the aldehydefuchsin positive nerve fibres of this region and that they do not originate from the magnocellular neurosecretory hypothalamic nuclei. The neurophysin-like substance-containing, aldehyde-fuchsin positive nerve fibres of the external region of the median eminence could be the terminal arborizations of a putative vasopressin or (and) corticotropin releasing factor producing suprachiasmatic-infundibular system.
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This work was supported in part by a grant from the National Fonds voor Geneeskundig Wetensehappelijk Onderzoek.
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Vandesande, F., De Mey, J. & Dierickx, K. Identification of neurophysin producing cells. Cell Tissue Res. 151, 187–200 (1974). https://doi.org/10.1007/BF00222222
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DOI: https://doi.org/10.1007/BF00222222