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Enhanced K-cell activity in the peripheral blood of patients with malignant disease

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Summary

We have analysed the influence of human malignant, inflammatory and infectious disease on the capacity of peripheral lymphocytes to mediate antibody-dependent haemolysis. The application of an enzyme-like kinetic model for measurement of maximal cytotoxic function has permitted reproducible and sensitive determinations of the K-cell function. The results show that malignant disease is associated with enhancement of ADCC capacity.

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Authors and Affiliations

  1. National Institute of Oncology, Ráth Gy. u. 7-9, Budapest XII., Hungary

    Tibor Bakács & Gábor Ringwald

  2. Bajcsy-Zsilinszky Hospital, Köbányai ut 45, Budapest X., Hungary

    Pál Czanik & Erzsébet Ábrahám

  3. Department of Immunology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, M20 9BX, Manchester, U.K.

    Ian Kimber & Michael Moore

Authors
  1. Tibor Bakács
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  2. Pál Czanik
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  3. Ian Kimber
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  4. Gábor Ringwald
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  5. Michael Moore
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  6. Erzsébet Ábrahám
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Bakács, T., Czanik, P., Kimber, I. et al. Enhanced K-cell activity in the peripheral blood of patients with malignant disease. Cancer Immunol Immunother 16, 170–174 (1984). https://doi.org/10.1007/BF00205424

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  • DOI: https://doi.org/10.1007/BF00205424

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