Summary
The authors report a case of a balanced 1;17 translocation with breakpoints located in the secondary constriction of chromosome 1. This translocation is associated with pathological symptoms similar to those observed following a proximal deletion of 1q. We request contact with colleques who have observed similar, or related, cases of translocation with breakpoints in heterochromatic regions of human chromosomes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cook HJ, Hindley J (1979) Cloning of human satellite III DNA: different components are on different chromosomes. Nucleic Acids Res 6:3177–3197
Schinzel A (1984) Catalogue of unbalanced chromosome aberration in man. deGruyter, Berlin New York
Vorsanova SG, Yurov YB, Alexandrov IA, Mitkevich SP, Tirskaia AF (1986) 18p-syndrome: an unusual case and diagnosis by in situ hybridization with chromosome 18-specific alphoid DNA sequences. Hum Genet 72:185–187
Yurov YB, Yakovlev AG, Alexandrov IA, Mitkevich SP, Rogaev EI, Vorsanova SG (1989) Collection of alpha-satellite DNA robes: highly polymorphic markers for centromeric regions of all human chromosomes. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:114
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vorsanova, S.G., Yurov, Y.B., Kurbatov, M.B. et al. Translocation t(1;17)(q12;q25) with a clinical picture like of a proximal deletion of 1q: identification by in situ hybridization with chromosome 1-specific satellite DNA probes. Hum Genet 86, 173–174 (1990). https://doi.org/10.1007/BF00197700
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00197700