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Factor XIIIa-positive dendrocytes and proliferative activity of cutaneous cancers

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Abstract

Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells. Factor XIIIa, other tissue transglutaminases, α2-macroglobulin and tumour necrosis factor-α represent a complex network of mediators influencing tumour progression in the skin. In the present study we searched for the presence of dendrocytes and α2-macroglobulin deposits inside and in the vicinity of cutaneous carcinomas (90 basal cell carcinomas and 46 squamous cell carcinomas) and malignant melanomas (69 primary and 28 metastatic tumours). We also studied the proliferation of the same neoplasms by Ki-67 immunohistochemistry. Dendrocytes were numerous, abutting on and infiltrating most basal cell carcinomas and thin malignant melanomas. In contrast, they were present in only low numbers or even absent in thick primary malignant melanomas and in their metastases. They appeared unmodified around squamous cell carcinomas compared with the surrounding skin. Extracellular deposits of α2-macroglobulin were often found in locations where dermal dendrocytes were numerous. No correlation was found between the Ki-67 indices of carcinomas and the density of peritumoral dendrocytes. In contrast, negative relationships were found between the Ki-67 indices and the number of dendrocytes present inside basal cell carcinomas and thin malignant melanomas. This study has yielded circumstantial evidence to link the density of factor XIIIa-positive dendritic cells and a low proliferative rate of neoplastic cells in basal cell carcinomas and malignant melanomas.

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References

  1. Al-Saleh W, Delvenne P, Greimers R, Fridman V, Doyen J, Boniver J (1995) Assessment of Ki-67 antigen immunostaining in squamous intraepithelial lesions of the uterine cervix. Correlation with the histologic grade and human papillomavirus type. Am J Clin Pathol 104: 154–160

    Google Scholar 

  2. Arrese Estrada J, Piérard GE (1990) Factor XIIIa-positive dendrocytes and the dermal microvascular unit. Dermatologica 180: 51–53

    Google Scholar 

  3. Bugelski PJ, Corwin SP, North SM, Kirsch RL, Nicolson GL, Poste G (1987) Macrophage content of spontaneous metastases at different stages of growth. Cancer Res 47: 4141–4145

    Google Scholar 

  4. Cerio R, Spaull J, Jones W (1989) Histiocytoma cutis: a tumor of dermal dendrocytes (dermal dendrocytoma). Br J Dermatol 120: 197–206

    Google Scholar 

  5. Cerio R, Griffiths CEM, Cooper KD, Nickoloff BJ, Headington JT (1989) Characterization of factor XIIIa-positive dermal dendritic cells in normal and inflamed skin. Br J Dermatol 121: 421–431

    Google Scholar 

  6. Cerio R, Spaull J, Oliver GF, Wilson Jones E (1990) A study of factor XIIIa and Mac 387 immunolabeling in normal and pathological skin. Am J Dermatopathol 12: 221–233

    Google Scholar 

  7. Davies PJA, Davies DR, Levitzki A, Maxfield FR, Milhaud P, Willinghma MC, Patsan IH (1980) Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature 283: 162–167

    Google Scholar 

  8. Delvenne P, Al-Saleh W, Gillis C, Thiry A, Boniver J (1995) Inhibition of growth of normal and human papillomavirus-transformed keratinocytes in monolayer and organotypic cultçures by interferon gamma and tumor necrosis factor alpha. Am J Pathol 146: 589–598

    Google Scholar 

  9. Denton KJ, Cotton DWK, Wright A, Hird P (1990) Factor XIIIa in nodular malignant melanoma and Spitz naevi. Br J Dermatol 123: 783–786

    Google Scholar 

  10. Fogt F, Vortmeyer AO, Tahan SR (1995) Nucleolar organizer regions (AgNOR) and Ki-67 immunoreactivity in cutaneous melanocytic lesions. Am J Dermatopathol 17: 12–17

    Google Scholar 

  11. Graves D, Valente A (1990) Monocyte chemoattractants produced by malignant cells. J Pathol (Lond) 161: 187–188

    Google Scholar 

  12. Hoyo E, Kanitakis J, Schmitt D (1993) Le dendrocyte dermique. Pathol Biol 41: 613–618

    Google Scholar 

  13. Knight CRL, Rees RC, Griffin M (1991) Apoptosis: a potential role for cytosolic transglutaminase and its importance in tumour progression. Biochim Biophys Acta 1096: 312–318

    Google Scholar 

  14. Kratochwil K (1986) The stroma and the control of cell growth. J Pathol (Lond) 149: 23–24

    Google Scholar 

  15. Liotta LA, Guirguis R, Stracke M (1987) Biology of melanoma invasion and metastasis. Pigment Cell Res 1: 5–15

    Google Scholar 

  16. Matoska J, Wahlström T, Vaheri A, Brizik J, Grofova M (1988) Tumor-associated alpha 2-macroglobulin in human melanomas. Int J Cancer 41: 359–363

    Google Scholar 

  17. Nestle FO, Nickoloff BJ (1995) A fresh morphological and functional look at dermal dendritic cells. J Cutan Pathol 22: 385–393

    Google Scholar 

  18. Nestle FO, Zheng XG, Thompson CB, Turka LA, Nickoloff BJ (1993) Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol 151: 6535–6545

    Google Scholar 

  19. Nickoloff BJ, Griffiths CEM (1990) Lymphocyte trafficking in psoriasis: a new perspective emphasizing the dermal dendrocyte with active dermal recruitement mediated via endothelial cells followed by intra-epidermal T-cell activation. J Invest Dermatol 95: 35s-37s

    Google Scholar 

  20. Ossowski L, Reich E (1983) Changes in malignant phenotype of a human carcinoma conditioned by growth environment. Cell 33: 323–333

    Google Scholar 

  21. Piérard GE, Piérard-Franchimont C, Henry C, Lapière M (1984) The proliferative activity of cells of malignant melanomas. Am J Dermatopathol 6 [Suppl 1]: 317–324

    Google Scholar 

  22. Piérard GE, Arrese Estrada J, Piérard-Franchimont C, Deleixhe-Mauhin F (1990) Is there a link between dendrocytes, fibrosis and sclerosis? Dermatologica 181: 264–265

    Google Scholar 

  23. Piérard GE, Nikkels A, Arrese Estrada J, Ben Mosbah T, Piérard-Franchimont C (1991) Dermal dendrocytes and photochemotherapy. Virchows Arch [A] 418: 311–314

    Google Scholar 

  24. Piérard GE, Piérard-Franchimont C, Hermanns-Lê T, Arrese Estrada J (1992) Factor XIIIa-positive dendritic cells in mycosis fungoides. Cancer J 5: 226–229

    Google Scholar 

  25. Piérard-Franchimont C, Piérard GE, Van Cauwenberge D, Damseaux M, Lapière CM (1982) Episodic progression and regression of basal cell carcinomas. Br J Dermatol 106: 305–310

    Google Scholar 

  26. Piérard-Franchimont C, Arrese Estrada J, Nikkels A, Deleixhe-Mauhin F, Piérard GE (1990) Dendrocytes et cellules dendritiques épidermiques au cours du photovieillissement. Ann Dermatol Vénéréol 117: 965–967

    Google Scholar 

  27. Piérard-Franchimont C, Fazaa B, Benzarti H, Kort R, Arrese JE, Nikkels AF, Kamoun MR, Piérard GE (1994) Phenotypic heterogeneity in the fibroblast-like cells of the dermis. Giorn Int Dermatol Pediatr 6: 7–13

    Google Scholar 

  28. Seiving B, Ohlsson K, Linder C, Stenberg P (1991) Transglutaminase differentiation during maturation of human blood monocytes to macrophages. Eur J Haematol 46: 263–271

    Google Scholar 

  29. Smolle J, Soyer HP, Kerl H (1989) Proliferative activity of cutaneous melanocytic tumors defined by Ki-67 monoclonal antibody. A quantitative immunohistochemical study. Am J Dermatopathol 11: 301–307

    Google Scholar 

  30. Soyer HP (1991) Ki-67 immunostaining in melanocytic skin tumors. Correlation with histologic parameters. J Cutan Pathol 18: 264–272

    Google Scholar 

  31. Trimble CL, Gray MH, McNutt NC (1992) The distribution of Factor XIIIa-positive cells in the human fetus and placenta. Virchows Arch [A] 420: 513–518

    Google Scholar 

  32. Van den Hooff A (1988) Stroma involvement in malignant growth. Adv Cancer Res 50: 152–196

    Google Scholar 

  33. Zipori D (1990) Stromal cells in tumor growth and regression. Cancer J 3: 164–169

    Google Scholar 

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Authors and Affiliations

  1. Department of Dermatopathology, University of Liège, CHU Sart Tilman, B-4000, Liège, Belgium

    Claudine Piérard-Franchimont, Jorge E. Arrese, Arjen F. Nikkels & Géerald E. Piérard

  2. Department of Pathology, University of Liège, CHU Sart Tilman, B-4000, Liège, Belgium

    Walid Al-Saleh & Philippe Delvenne

Authors
  1. Claudine Piérard-Franchimont
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  2. Jorge E. Arrese
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  3. Arjen F. Nikkels
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  4. Géerald E. Piérard
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  5. Walid Al-Saleh
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  6. Philippe Delvenne
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Piérard-Franchimont, C., Arrese, J.E., Nikkels, A.F. et al. Factor XIIIa-positive dendrocytes and proliferative activity of cutaneous cancers. Vichows Archiv A Pathol Anat 429, 43–48 (1996). https://doi.org/10.1007/BF00196819

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  • DOI: https://doi.org/10.1007/BF00196819

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