Summary
A controlled shift down of the specific growth rate in a fed batch culture is proposed for microbial product formation processes. The growth kinetics depend on three preset parameters: initial biomass concentration, initial specific growth rate, and the transient constant (time derivative of the specific growth rate). An experimental example is given.
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Guthke, R., Gira, G., Mund, K. et al. Computer controlled transient state in a fed batch culture. Biotechnol Lett 2, 315–320 (1980). https://doi.org/10.1007/BF00172644
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DOI: https://doi.org/10.1007/BF00172644