Abstract
The locomotor response to RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl) 1H-indole; 10 mg/kg, s.c.), a preferential 5-HT1B receptor agonist, was investigated in the rat, using two novel 5-HT1A receptor antagonists, WAY-100635 (0.3 mg/kg and 1 mg/kg, s.c.) and SDZ 216-525 (0.3 mg/kg, s.c.), and the novel 5-HT1B/5-HT1D receptor antagonist, GR 127935 (1 mg/kg, s.c.). The antagonists per se did not alter spontaneous locomotion. Both selective 5-HT1A receptor antagonists blocked RU 24969-induced hyperlocomotion, whilst the 5-HT1B receptor antagonist was without effect. These results suggest that RU 24969-induced hyperlocomotion in the rat is mediated by 5-HT1A receptors.
Similar content being viewed by others
References
Cheetham SC, Heal DJ (1993) Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor. Br J Pharmacol 110:1621–1629
Chopin P, Moret C, Briley M (1994) Neuropharmacology of 5-hydroxytryptamine1B/1D receptor ligands. Pharmacol Ther 62:385–405
Fletcher A, Bill DJ, Cliffe IA, Forster EA, ones D, Reilly Y (1994) A pharmacological profile of WAY-100635, a potent and selective 5-HT1A receptor antagonist. Br J Pharmacol 112:91P
Hartley JE, Brown G, Fletcher A, Dourish CT (1995) Evidence for the involvement of 5-HT2B–2C receptors in mediating fenfluramine-induced anorexia in rats. Br J Pharmacol 114:373P
Hoyer D (1988) Functional correlates of serotonin 5-HT1 recognition sites. J Recept Res 8:59–81
Kennett GA, Curzon G (1988) Evidence that hypophagia induced by mCPP and TFMPP requires 5-HTI1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. Psychopharmacology 96:93–100
Schoeffter P, Fozard JR, Stoll A, Seiler MP, Hoyer D (1993) SDZ 216–525, a selective and potent 5-HT1A receptor antagonist. Eur J Pharmacol 244:251–257
Skingle M, Higgins GA, Feniuk W (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig. J Psychopharmacol 8:14–21
Tricklebank MD, Middlemiss DN, Neill J (1986) Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat. Neuropharmacology 25:877–886
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kalkman, H.O. RU 24969-induced locomotion in rats is mediated by 5-HT1A receptors. Naunyn-Schmiedeberg's Arch Pharmacol 352, 583–584 (1995). https://doi.org/10.1007/BF00169395
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00169395