Summary
Immunoreactivities (IR) of substance P and leucine enkephalin have been demonstrated in the guinea-pig paracervical ganglion by an immunogold electron microscope method. Both substance P-IR and leucine enkephalin-IR were detected in large synaptic vesicles with electron-dense cores. The former neuropeptide was detected in nerve terminals and varicosities comprised mainly of large vesicles with electron-dense cores; the latter was detected in nerve terminals and varicosities that also included small, clear synaptic vesicles. In a minority of nerve terminals and varicosities coexistence of both immunoreactivities could be demonstrated within vesicles with an electron-dense core. Also present in these nerve terminals and varicosities were small, clear synaptic vesicles, though these were unreactive.
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Mitchell, B.S., Stauber, V.V. Localization of substance P and leucine enkephalin in the nerve terminals of the guinea pig paracervical ganglion. Histochem J 25, 144–149 (1993). https://doi.org/10.1007/BF00157987
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DOI: https://doi.org/10.1007/BF00157987