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Changes in gene frequencies at the octanol dehydrogenase locus of Drosophila melanogaster imposed by environmental ethanol

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Abstract

Experiments have been performed to study the effect of selection at the Odh locus in Drosophila melanogaster populations using different alcohol concentrations in the medium. The data can be best interpreted by assuming frequency-dependent selection. When genotype frequencies are considered as independent variables and values of Wrightian fitness as dependent variables, it turns out that different functions describe the selection of the coexisting genotypes. A linear equation is used for the SF genotype and a hyperbolic function for the FF genotype. No function of good fit could be found for the SS genotype. Simulation experiments using these functions fit our data well.

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References

  • Bijlsma-Meeles, E. & Van Delden, W., 1974. Intra- and interpopulation selection concerning the alcohol dehydrogenase locus in Drosophila melanogaster. Nature 247: 369–371.

    Google Scholar 

  • Caverner, D. R., & Clegg, M. T., 1981. Multigenic response to ethanol in Drosophila melanogaster. Evolution 35 (1): 1–10.

    Google Scholar 

  • Courtright, J. B., Imberski, R. R. & Ursprung, H., 1966. The genetic control of alcohol dehydrogenase and octanol dehydrogenase isozymes in Drosophila. Genetics 54: 1251–1260.

    Google Scholar 

  • Dolan, R. & Robertson, A., 1975. The effect of conditioning the medium in Drosophila in relation to frequency-dependent selection. Heredity 35: 311–316.

    Google Scholar 

  • Fontdevila, A. & Mendez, J., 1979. Frequency-dependent mating in a modified allozyme locus of Drosophila pseudoobscura. Evolution 33 (2): 634–640.

    Google Scholar 

  • Gibson, J. B., Lewis, N., Adena, M. A. & Wilson, S. R., 1979. Selection for ethanol tolerance in two populations of Drosophila melanogaster. Segregating alcohol dehydrogenase allozymes. Aust. J. Biol. Sci. 32: 387–398.

    Google Scholar 

  • Grell, E. H., Jacobson, K. B. & Murphy, J. B., 1965. ADH in Drosophila melanogaster: Isozymes and genetic variants. Science 149: 80–82.

    Google Scholar 

  • Huang, S. L., Singh, M. & Kojima, K., 1970. A study of frequency-dependent selection observed in the esterase-6 locus of Drosophila melanogaster using conditioned media method. Genetics 68: 97–104.

    Google Scholar 

  • Kojima, K. & Tobari, Y. N., 1969. The pattern of viability changes associated with genotype frequency at the alcohol dehydrogenase locus in a population of Drosophila melanogaster. Genetics 61: 201–209.

    Google Scholar 

  • Kojima, K. & Yarbrough, K. M., 1967. Frequency-dependent selection at the esterase-6 locus in Drosophila melanogaster. Genetics 57: 645–649.

    Google Scholar 

  • Manly, B. F. J., 1985. The statisties of natural selection on animal populations. Chapman & Hall, London, New York.

    Google Scholar 

  • Morgan, P., 1975. Selection acting directly on an enzyme polymorphism. Heredity 34: 124–127.

    Google Scholar 

  • Morgan, N. P., 1976. Frequency-dependent selection at two enzyme loci in Drosophila melanogaster. Nature 263: 765–766.

    Google Scholar 

  • Nagylaki, T., 1977. Selection in one- and two-locus systems. Lecture notes in biomathematics. 15: 51–60. Springer, Berlin.

    Google Scholar 

  • Oakeshott, J. G., 1976. Selection at the alochol dehydrogenase locus in Drosophila melanogaster imposed by environmental ethanol. Genet. Res. 26: 265–274.

    Google Scholar 

  • Oakeshott, J. G., Gibson, J. B., Anderson, P. R. & Champ, A., 1980. Opposing modes of selection on the alcohol dehydrogenase locus in Drosophila melanogaster. Aust. J. Biol. Sci. 33: 105–114.

    Google Scholar 

  • Oakeshott, J. G., Gibson, J. B. & Wilson, S. R., 1984. Selective effects of the genetic backgroup and ethanol on the alcohol dehydrogenase polymorphism in Drosophila melanogaster. Heredity 53 (1): 51–67.

    Google Scholar 

  • Palabost-Charles, L., 1979. Maintenance mechanism of polymorphism at the α-Gpdh locus in Drosophila melanogaster. Biochem. Genet. 17: 905–913.

    Google Scholar 

  • Palabost-Charles, L., 1980. Maintenance mechanism of polymorphism at the α-Gpdh locus in Drosophila melanogaster. Biochem. Genet. 18: 905–913.

    Google Scholar 

  • Pot, W., Van Delden, W. & Kruijt, J. P., 1980. Genotypic differences in mating success and the maintenance of the alcohol dehydrogenase polymorphism in Drosophila melanogaster: No evidence for overdominance or rare genotype mating advantage. Behaviour Genet. 10 (1): 43–58.

    Google Scholar 

  • Schwartz, M., & Sofer, W., 1976. Alcohol dehydrogenase negative mutants in Drosophila: Defects at the structural locus? Genetics 83: 125–236.

    Google Scholar 

  • Van Delden, W., 1982. The alcohol dehydrogenase polymorphism in Drosophila melanogaster. Selection at an enzyme locus. Evol. Biol. 15: 187–222.

    Google Scholar 

  • Vigue, C. L., Weisgram, P. A. & Rosenthal, E., 1982. Selection at the alcohol dehydrogenase locus of Drosophila melanogaster: Effects of ethanol and temperature. Biochem. Genet. 20 (7/8): 681–688.

    Google Scholar 

  • Wills, S. C. & Nichols, L., 1971. Single-gene heterosis in Drosophila by inbreeding. Nature 233: 123–125.

    Google Scholar 

  • Wills, S. C., Phelps, J. & Ferguson, R., 1975. Further evidence for selective differences between isoalleles in Drosophila. Genetics 79: 127–141.

    Google Scholar 

  • Wilson, S. R., Oakeshott, J. G., Gibson, J. B. & Anderson, P. R., 1982. Measuring selection coefficients affecting the alcohol dehydrogenase polymorphism in Drosophila melanogaster. Genetics 100: 113–126.

    Google Scholar 

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Pecsenye, K., Lörincz, G. Changes in gene frequencies at the octanol dehydrogenase locus of Drosophila melanogaster imposed by environmental ethanol. Genetica 77, 171–177 (1988). https://doi.org/10.1007/BF00122387

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  • DOI: https://doi.org/10.1007/BF00122387

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