Skip to main content
SpringerLink
Log in

Genetic linkage in the Norway rat

  • Published:
Genetica Aims and scope Submit manuscript

Abstract

The present status of research on genetic linkage is reviewed. Where possible, the data are statistically combined to give consolidated estimates of the recombination value. Ten groups of linked genes have been determined. The first assignments of linkage groups to specific chromosomes have been facilitated by inter-species cell hybridisation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adams, M., Baverstock, P. R., Watts, C. H. S. & Gutman, G. A., 1984. Enzyme markers in inbred rat strains: genetics of new markers and strain profiles. Biochem. Genet. 22: 611–629.

    Google Scholar 

  2. Baranov, V. S. et al., 1984. [Mapping the transferrin gene in the rat.] Genetika. USSR, 20: 1984–1593.

    Google Scholar 

  3. Battisto, J. R., Smith, R. N., Beckman, K., Sternlicht, M. & Welles, W. (1982). Susceptibility to adjuvant arthritis in DA and F344 rats. Arthr. Rheumat. 25: 1194–1200.

    Google Scholar 

  4. Beckers, A. & Bazin, H., 1975. Allotypes of rat immunoglobulins. Immunochemistry 12: 671–675.

    Google Scholar 

  5. Bender, K., Nagel, M., Muller, C. R. & Gunther, E., 1979. Electrophoretic protein variants in inbred strains of Rattus norvegicus. Transpl. Proc. 11: 1653–1656.

    Google Scholar 

  6. Blankenhorn, E. P. & Cramer, D. V., 1985. Orientation of the loci encoding RBI. B polypeptides in the major histocompatibility complex of the rat. Immunogenetics 21: 135–142.

    Google Scholar 

  7. Brdicka, R., 1968. The chromosome I of the laboratory rat. Acta Univ. Carol. Med. 14: 93–98.

    Google Scholar 

  8. Brdicka, R., Kren, V. & Franzl, B., 1978. Linkage of alloantigenic locus H-3 and plasma locus Es-2 in the Norway rat. Folia Biol. (Praha) 24: 381–382.

    Google Scholar 

  9. Butcher, G. W., Clarke, S. & Tucker, E. M., 1979. Close linkage of peripheral T-lymphocyte antigen A (PtaA) to the haemoglobin variant Hbb on linkage group I of the rat. Transpl. Proc. 11: 1629–1630.

    Google Scholar 

  10. Castle, W. E., 1953. Silver, a new mutation of the rat. J. Hered. 44: 205–206.

    Google Scholar 

  11. Castle, W. E. & King, H. D., 1941. Linkage studies of the rat. V. Proc. natn. Acad. Sci. U.S.A. 27: 394–398.

    Google Scholar 

  12. Castle, W. E. & King, H. D., 1944. Linkage studies of the rat. VI. Proc. natn. Acad. Sci. U.S.A., 30: 79–82.

    Google Scholar 

  13. Castle, W. E. & King, H. D., 1947. Linkage studies of the rat. VII. J. Hered. 38: 341–343.

    Google Scholar 

  14. Castle, W. E. & King, H. D., 1949. Linkage studies of the rat. X. Proc. natn. Acad. Sci. U.S.A. 35: 545–546.

    Google Scholar 

  15. Committee for a standard karyotype of Rattus norveglcus, 1973. Cytogenet. Cell Genet. 12: 199–205.

    Google Scholar 

  16. Cramer, D. V., 1981. Genetic variation of urinary pepsinogen and its probable linkage to albinism in the rat. Immunogenetics 13: 555–558.

    Google Scholar 

  17. Cramer, D. V., 1983. Linkage of quantitative variation of a serum protein (Sp) to the MHC of the rat. Immunogenetics 18: 593–598.

    Google Scholar 

  18. Cramer, D. V., Blankert, J. J. & Paul, L. C., 1985. Linkage of loci encoding a kidney endothelial antigen and fumarate hydratase (Fh-1) in the rat. Biochem. Genet. 23: 623–629.

    Google Scholar 

  19. Dewitt, C. W. & McCullough, M., 1975. Serological and genetic identifications of a new locus in the rat governing lymphocyte membrane antigens. Transplantation 19: 310–317.

    Google Scholar 

  20. Dunning, W. F. & Curris, M. R., 1939. Linkage in rats between factors determining a pathological condition and a coat colour. Genetics 24: 70.

    Google Scholar 

  21. Ferguson, F. G., Irving, G. W. & Stedham, M. A., 1979. Three variations of hairlessness associated with albinism in the laboratory rat. Lab. Anim. Sci. 29: 459–465.

    Google Scholar 

  22. French, E. A., Roberts, K. B. & Searle, A. G., 1971. Linkage between a hemoglobin locus and albinism in the Norway rat. Biochem. Genet. 5: 397–404.

    Google Scholar 

  23. Gasser, D. L., 1972, Seminal vesicle protein in rats. Biochem. Genet 6: 61–63.

    Google Scholar 

  24. Gasser, D. L., 1981. The organisation of immunogenetic loci in the Norway rat. Transpl. Proc. 13: 1311–1316.

    Google Scholar 

  25. Gasser, D. L., Silvers, W. K., Reynolds, H. M., Black, G. & Palm, J., 1973. Serum esterase genetics in rats. Biochem. Genet. 10: 207–217.

    Google Scholar 

  26. Gill, T. J., Cramer, D. V., Kunz, H. W. & Misra, D. N., 1983. Structure and function of the MHC of the rat. J. Immunogenet. 10: 261–273.

    Google Scholar 

  27. Gill, T. J. & Kunz, H. W. 1979. Gene complex controlling growth and fertility linked to the MHC in the rat. Amer. J. Pathol. 96: 185–206.

    Google Scholar 

  28. Gill, T. J., Kunz, H. W., Schald, D. J., VandeBerg, J. L. & Stole, V. 1982. Orientation of loci in the MHC of the rat. J. Immunogenet. 9: 281–293.

    Google Scholar 

  29. Greaves, J. H. & Ayres, P., 1969. Linkage between genes for coat colour and resistance to warfarin in Rattus norvegicus. Nature 224: 284–285.

    Google Scholar 

  30. Greaves, J. H. & Ayres, P., 1976. Inherltance of Scottish-type resistance to warfarin in the Norway rat. Genet. Res. 28: 231–239.

    Google Scholar 

  31. Greaves, J. H. & Ayres, P., 1977. Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark. Genet. Res. 29: 215–222.

    Google Scholar 

  32. Greiner, D. L., Barton, R. W., Goldschneider, I. & Lubaroff, D. M., 1982. Genetic linkage and cell distribution analysis of T cell alloantigens in the rat. J. Immunogenet 9: 43–50.

    Google Scholar 

  33. Gruneberg, H. 1939. The linkage relations of a new lethal gene in the rat. Genetics 24: 732–741.

    Google Scholar 

  34. Gumbock, L. G. & Stanley, A. J., 1986. Linkage of genes for octopic testes and male pseudohermaphroditism in the rat. J. Hered 77: 57.

    Google Scholar 

  35. Gutman, G. A., Bazin, H., Rokhlin, O. V. & Nezlin, R. S., 1983. Standard nomenclature for rat immunoglobulin allotypes. Transpl. Proc. 15: 1685–1686.

    Google Scholar 

  36. Heslop, B. F. & Jolly, K. D., 1979. Genetic control of haemogglutinin production against an MHC determined alloantigen in rats. Immunogenetics 8: 567–570.

    Google Scholar 

  37. Kendall, P. B., 1985. Glucose phosphate dehydrogenase polymorphism and the genetics of linkage group II in the Norway rat. Lab. Anim. 19: 169–172.

    Google Scholar 

  38. Knox, W. E. & Lister-Rosenov, L. M., 1978. Infantile ichthyosis in rats. J. Hered. 69: 391–394.

    Google Scholar 

  39. Kondo, Y. & Yamada, J., 1983. Polymorphism of urinary pepsinogen-1 locus in the rat and its linkage analysis. Exp. Anim. 32: 51–54.

    Google Scholar 

  40. Kren, V., 1975. Genetics of the polydactyly-luxate syndrome in the Norway rat. Acta Univ. Carol. Med. 68: 1–103.

    Google Scholar 

  41. Kunz, H. W., Misra, D. N. & Gill, T. J., 1985. Production of monoclonal antibodies against RT2 antigens of the rat and the definition of a new locus. RT9, liked to RT2. J. Immunogenet. 12: 75–78.

    Google Scholar 

  42. LaVail, M. M., 1981. Assignment of retinal dystrophy to linkage group IV of the rat. J. Hered. 72: 294–296.

    Google Scholar 

  43. Lindena, G., 1981. Biochemical genetics of rat esterases. Biochem. Genet. 19: 1079–1090.

    Google Scholar 

  44. Lubaroff, D. M. et al., 1983. Standardised nomenclature for the rat T-cell allcantigens. Transpi. Proc. 15: 1683.

    Google Scholar 

  45. Matsumato, K., 1980. New polymorphisms of esterase 7 and 8 in inbred strains of rats. Biochem. Genet. 18: 879–887.

    Google Scholar 

  46. Matsumoto, K., McCafferty, E., Neilson, E. G. & Gasser, D. L., 1984. Mapping of the genes for tubular basement membrane antigen and sub-maxilary gland protease in the rat. Immunogenetics 20: 117–123.

    Google Scholar 

  47. Mizumo, M. & Suzuki, K., 1978. Genetic variation of pancreatic amylase in the rat. Jap. J. Genet. 53: 137–148.

    Google Scholar 

  48. Moutier, R., 1980. Linkage of the hypodactylyl and incisorless genes in the Norway rat. J. Hered. 71: 129–130.

    Google Scholar 

  49. Moutier, R., Toyama, K. & Charrier, M. F., 1973. Biochemical polymorphism in the rat. Biochem. Genet. 8: 321–328.

    Google Scholar 

  50. Moutier, R., Toyama, K. & Charrier, M. F., 1973. Linkage of a plasma protein marker (Gl-1) and the hooded locus in the rat. Biochem. Genet. 10: 395–398.

    Google Scholar 

  51. Nikaido, H., Yamada, J. & Kondo, Y., 1982. Male urinary protein (Mup-I) in the rat. J. Hered. 73: 119–122.

    Google Scholar 

  52. Olkawa, T. et al., 1983. Provisional chromosome assignment of the rat MHC. Jap. J. Genet. 58: 327–336.

    Google Scholar 

  53. Palm, J. & Ferguson, F. G., 1976. Fuzzy, a hypotrichotic mutant in linkage group I of the Norway rat. J. Hered. 67: 284–288.

    Google Scholar 

  54. Perlmann, C., Sumegi, J., Szpirer, C., Levan, G. & Klein, G., 1985. The rat immunoglobulin kappa light chain locus is on chromosome 4. Immunogenetics 22: 97–100.

    Google Scholar 

  55. Robinson, R., 1960. A review of independent and linked segregation in the Norway rat. J. Genet. 57: 173–192.

    Google Scholar 

  56. Robinson, R., 1971. Gene mapping in laboratory mammals. Part A. Plenum Press.

  57. Robinson, R., 1972. Gene mapping in laboratory mammals. Part B. Plenum Press.

  58. Robinson, R., 1981. Rex mutant in the Norway rat. J. Hered. 72: 131–132.

    Google Scholar 

  59. Shumiya, S. & Nagase, S., 1982. Linkage of the analbuminemia locus and the hooded locus in the rat. Exp. Anim. 31: 199–202.

    Google Scholar 

  60. Skow, L. C., Kunz, H. W. & Gill, T. J., 1985. Linkage of the locus encoding the A chain of α-crystallin (Acry-1) to the major histocompatibility complex in the rat. Immunogenetics 22: 291–293.

    Google Scholar 

  61. Stolc, V., 1984. Linkage of hooded and hood-modifier genes in the rat. J. Hered. 75: 81.

    Google Scholar 

  62. Stolc, V. 1985. Linkage of hooded, agouti and diabetes insipidus genes in the rat. Transpl. Proc. 17: 1891–1892.

    Google Scholar 

  63. Stolc, V. & Gill, T. J., 1983. Linkage and polymorphism of a gene controlling lactate dehydrogenase in the rat. Biochem. Genet. 21: 933–941.

    Google Scholar 

  64. Stolc, V., Kunz, H. W. & Gill, T. J., 1980. The linkage of glyoxylase-1 to the MHC in the rat. J. Immunol. 125: 1167–1170.

    Google Scholar 

  65. Szipirer, J., Defeo-Jones, D., Ellis, R. W., Levan, G. & Szipirer, C., 1985. Assignment of three rat cellular RAS oncogenes to chromosome 1,4 and X. Somatic Cell molec, Genet. 11: 93–97.

    Google Scholar 

  66. Szipirer, J., Levan, G., Thorn, M. & Szpirer, C. 1984. Gene mapping in the rat by mouse-rat somatic cell hybridisation. Cytogenet. Cell Genet. 38: 142–149.

    Google Scholar 

  67. Vanderberg, J. L., Bittner, G. N., Meyer, G. S., Kunz, H. W. & Gill, T. J., 1981. Linkage of neuraminidase and mannosidase to the MHC in the rat. J. Immunogenet. 8: 239–242.

    Google Scholar 

  68. Womack, J. E., 1973. Biochemical genetics of rat esterase. Biochem. Genet. 9: 13–24.

    Google Scholar 

  69. Womack, J. E. & Sharp, M., 1976. Genetics of esterases in Mus musculus and Rattus norvegicus. Genetics 82: 665–675.

    Google Scholar 

  70. Yamada, J., Nikaido, H. & Kondo, Y., 1981. Genetic studies of RDC catalase in the rat. Jap. J. Genet. 56: 447–455.

    Google Scholar 

  71. Yamada, J., Nikaido, H. & Matsumoto, S., 1980. Linkage analysis among five esterase loci in the laboratory rat. Biochem. Genet. 18: 433–438.

    Google Scholar 

  72. Yoshida, M. C., 1978. Rat gene mapping by rat-mouse somatic cell hydridisation. Cytogenet. Cell Genet. 22: 606–609.

    Google Scholar 

  73. Yoshida, M. C., 1979. Synteny of the genes for adenylate kinase and phosphoglucomutase in the rat. Proc. Jap. Acad. B. 55: 403–406.

    Google Scholar 

  74. Zutphen, L. F. M.van, 1983. Revision of the genetic nomenclature of esterase loci in the rat. Trans. Proc. 15: 1687–1688.

    Google Scholar 

  75. Zutphen, L. M. F.van, Bieman, M. & Kluge, R., 1985, Assignment of Lap-1 to linkage group I of the rat. Biochem. Genet. 23: 599–606.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Stephens Road Nursery, Ealing, W13 8HB, London, England

    R. Robinson

Authors
  1. R. Robinson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Robinson, R. Genetic linkage in the Norway rat. Genetica 74, 137–142 (1987). https://doi.org/10.1007/BF00055225

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00055225

Keywords

Search

Navigation