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Linkage Mapping: Localizing the Genes That Shape Human Variation

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Genome Mapping and Genomics in Human and Non-Human Primates

Part of the book series: Genome Mapping and Genomics in Animals ((MAPPANIMAL,volume 5))

Abstract

Linkage analysis has a long and successful history as a tool for localizing genes that shape human variation. This chapter provides a brief history of linkage analysis and an overview of linkage analysis methods used to map genes in human and nonhuman primate samples. The concepts behind linkage analysis are reviewed as basic approaches to Mendelian penetrance model-based, concordant and discordant sibling pair, and quantitative trait linkage. Examples of the successful application of these techniques in human and nonhuman primate studies are provided. Special challenges for linkage analysis in nonhuman primates and the role of linkage analysis in the whole genome sequence era are also discussed.

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Acknowledgments

This work was supported in part by NIH grants MH59490 and GM31575.

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Authors and Affiliations

  1. South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio, 3463 Magic Drive, Suite 320, San Antonio, TX, 78229, USA

    Laura Almasy

  2. Department of Genetics, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX, 78227, USA

    Mark Zlojutro Kos

  3. South Texas Diabetes and Obesity Institute, University of Texas at San Antonio Health Science Center Regional Academic Health Center, Harlingen, TX, 78550, USA

    John Blangero

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  1. Laura Almasy
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Correspondence to Laura Almasy .

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Editors and Affiliations

  1. South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio, Edinburg, Texas, USA

    Ravindranath Duggirala

  2. South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    Laura Almasy

  3. South Texas Diabetes and Obesity Institute, Brownsville, Texas, USA

    Sarah Williams-Blangero

  4. Faculty of Biomedical Sciences, Technology & Research, Sri Ramachandra University, Chennai, India

    Solomon F.D. Paul

  5. Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, West Bengal, India

    Chittaranjan Kole

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Almasy, L., Kos, M.Z., Blangero, J. (2015). Linkage Mapping: Localizing the Genes That Shape Human Variation. In: Duggirala, R., Almasy, L., Williams-Blangero, S., Paul, S., Kole, C. (eds) Genome Mapping and Genomics in Human and Non-Human Primates. Genome Mapping and Genomics in Animals, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46306-2_3

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