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RETRACTED ARTICLE: Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

Prostate cancer (PC) is a prevalent cancer in aged men. Curcumin is an active ingredient that has been extracted from the rhizome of the plant Curcuma longa. Recently, a potential of Curcumin against PC has been reported in PC, whereas the underlying molecular mechanisms are not completely understood. Here, we studied the effects of low-dose Curcumin on PC cell growth. Curcumin (from 0.2 to 0.8 μmol/l) dose-dependently inhibited the proliferation of PC cells, without affecting cell apoptosis. Further analyses showed that Curcumin dose-dependently increased a cell cycle suppressor CDKN1A at protein levels, but not mRNA levels, in PC cells, suggesting that Curcumin may regulate the translation of CDKN1A, as well as a possible involvement of miRNA intervention. From all CDKN1A-3′-UTR-binding miRNAs, we found that miR-208 was specifically inhibited in PC cells dose-dependently by Curcumin. Moreover, miR-208 was found to bind CDKN1A to suppress its expression. In a loss-of-function experiment, PC cells that overexpressed miR-208 failed to decrease cell proliferation in response to Curcumin. Together, these data suggest that Curcumin inhibits growth of PC via miR-208-mediated CDKN1A activation.

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Authors and Affiliations

  1. Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China

    Hui Guo, Yuemin Xu & Qiang Fu

Authors
  1. Hui Guo
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  2. Yuemin Xu
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  3. Qiang Fu
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Corresponding author

Correspondence to Qiang Fu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Guo, H., Xu, Y. & Fu, Q. RETRACTED ARTICLE: Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation. Tumor Biol. 36, 8511–8517 (2015). https://doi.org/10.1007/s13277-015-3592-y

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  • DOI: https://doi.org/10.1007/s13277-015-3592-y

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