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How and why do endophytes produce plant secondary metabolites?

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Abstract

Despite numerous studies reporting endophytic fungal production of metabolites chemically similar to the secondary metabolites produced by their host plants, how and why the fungi produce these metabolites remain largely unknown. Here, we review the literature on endophytic fungal production of taxol and camptothecin, two extensively studied plant secondary metabolites, and highlight critical gaps in our knowledge that need to be addressed to adequately answer the above questions. We show that detailed studies are required for conclusive demonstration of i) the production of these metabolites by the fungi, ii) the tolerance of the fungi to the produced cytotoxic metabolites, and iii) the adaptive significance of the metabolite production to the fungi. Although our focus is on two widely studied plant secondary metabolites produced by fungi, the questions addressed here are equally applicable to the production of a large number of other fungal metabolites that are similar to those produced by their host plants.

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Acknowledgements

The work reported here draws on research supported by the Department of Biotechnology, Government of India to Uma Shaanker. Sachin Naik and Selvadurai Dayanandan acknowledge the support from NSERC-Canada Discovery grant, and Uma Shaanker acknowledges Erasmus Mundus Travel Support to Uppsala University, Sweden.

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Authors and Affiliations

  1. Centre for Structural and Functional Genomics, Biology Department, Concordia University, 7141 Sherbrooke West, Montreal, QC, H4B1R6, Canada

    Sachin Naik & Selvadurai Dayanandan

  2. Quebec Centre for Biodiversity Sciences, 1205 Dr. Penfield Avenue, Montreal, QC, H3A1B1, Canada

    Sachin Naik & Selvadurai Dayanandan

  3. Department of Crop Physiology, University of Agricultural Sciences, Bangalore, Karnataka, 560065, India

    Ramanan Uma Shaanker

  4. Ashoka Trust for Research in Ecology and the Environment, Bangalore, Karnataka, 560064, India

    Gudasalamani Ravikanth

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  1. Sachin Naik
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  3. Gudasalamani Ravikanth
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Naik, S., Shaanker, R.U., Ravikanth, G. et al. How and why do endophytes produce plant secondary metabolites?. Symbiosis 78, 193–201 (2019). https://doi.org/10.1007/s13199-019-00614-6

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