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Molecular Neurobiology

, Volume 55, Issue 1, pp 445–461 | Cite as

Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum

  • Pranay Srivastava
  • Yogesh K. Dhuriya
  • Richa Gupta
  • Rajendra K. Shukla
  • Rajesh S. Yadav
  • Hari N. Dwivedi
  • Aditya B. Pant
  • Vinay K KhannaEmail author
Article

Abstract

Earlier, protective role of curcumin in arsenic-induced dopamine (DA)–D2 receptor dysfunctions in corpus striatum has been demonstrated by us. In continuation to that, the present study is focused to decipher the molecular mechanisms associated with alterations in dopaminergic signaling on arsenic exposure in corpus striatum and assess the protective efficacy of curcumin. Exposure to arsenic (20 mg/kg, body weight p.o. for 28 days) in rats resulted to decrease the expression of presynaptic proteins-tyrosine hydroxylase and VMAT2 while no effect was observed on the expression of DAT in comparison to controls. A significant decrease in the expression of DA-D2 receptors associated with alterations in the expression of PKA, pDARPP32 (Thr 34), and PP1 α was clearly evident on arsenic exposure. Expression of BDNF and pGSK3β in corpus striatum was found decreased in arsenic-exposed rats. Simultaneous treatment with curcumin (100 mg/kg, body weight p.o. for 28 days) resulted to protect arsenic-induced alterations in the expression of DA-D2 receptors, PKA, pDARPP32, pCREB, and pPP1α. Neuroprotective efficacy of curcumin can possibly be attributed to its antioxidant potential which significantly protected arsenic-induced mitochondrial dysfunctions by modulating the ROS generation and apoptosis. Modulation in the expression of BDNF and pGSK3β in corpus striatum by curcumin exhibits the importance of neuronal survival pathway in arsenic-induced dopaminergic dysfunctions. Interestingly, curcumin was also found to protect arsenic-induced ultrastructural changes in corpus striatum. The results exhibit that curcumin modulates BDNF/DARPP32/CREB in arsenic-induced alterations in dopaminergic signaling in rat corpus striatum.

Keywords

Dopamine Corpus striatum Arsenic Curcumin DARPP32 BDNF CREB 

Notes

Acknowledgements

The study has been carried out as a part of INDEPTH programme of Council of Scientific and Industrial Research (CSIR), New Delhi. The authors thank Director, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow, for his support throughout the study and Dr. LKS Chauhan, for the help to carry out experiments involving transmission electron microscopy. Pranay Srivastava and Richa Gupta are grateful to the Council for Scientific and Industrial Research, New Delhi, for the award of Senior Research Fellowship. Technical support by Mr. B.S. Pandey is acknowledged.

Compliance with Ethical Standards

All experiments were carried out in sync with the guidelines laid down by the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment and Forests (Government of India), New Delhi, India, and the experimental procedures were approved by the Institutional Animal Ethics Committee of CSIR-IITR, Lucknow (ITRC/IAEC/39/12).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Pranay Srivastava
    • 1
    • 2
  • Yogesh K. Dhuriya
    • 1
  • Richa Gupta
    • 1
    • 2
  • Rajendra K. Shukla
    • 1
  • Rajesh S. Yadav
    • 1
    • 3
  • Hari N. Dwivedi
    • 2
  • Aditya B. Pant
    • 1
  • Vinay K Khanna
    • 1
    Email author
  1. 1.Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment GroupCSIR-Indian Institute of Toxicology Research (CSIR-IITR)LucknowIndia
  2. 2.School of PharmacyBabu Banarasi Das UniversityLucknowIndia
  3. 3.Department of Criminology and Forensic Science, School of Applied SciencesDr. Harisingh Gour Central UniversitySagarIndia

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