Summary
This study investigated whether the curative effect of short-pulse gastric electrical stimulation (GES) on the vasopressin-induced dyspeptic symptoms was mediated by central opioid peptide-producing neurons. Five female beagle dogs implanted with 1 pair of electrodes in gastric serosa were used in a two-experiment study. In experiment one, the brain was scanned by positron emission tomography in 3 dogs with and without short-pulse GES, and the radioactivity in nuclei of solitary tract (NST) and hypothalamus was detected. Experiment two was composed of 4 sessions. In session one, the dogs were injected with vasopressin in the absence of short-pulse GES. With session two, the short-pulse GES was simultaneously given via the electrodes with the injection of vasopressin. In sessions three and four, naloxone and naloxone methiodide was administered respectively in the presence of short-pulse GES. Motion sickness-like symptoms were scored and compared among the different sessions. The results showed that the short-pulse GES significantly increased the radioactivity in NST and hypothalamic nuclei (P<0.05, vs control). The short-pulse GES could ameliorate the vasopressin-induced motion sickness-like symptoms in dogs. Naloxone, but not naloxone methiodide could attenuate the curative effects of short-pulse GES. It is concluded that NST and hypothalamic nuclei may participate in the mediation of the curative effects of short-pulse GES on dyspepsia-like symptoms. Central opioid peptide-containing neurons presumably mediate the therapeutic effect on dyspeptic symptoms of short-pulse GES.
Similar content being viewed by others
References
Talley NJ, Zinsmeister AR, Schleck CD, et al. Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology, 1992,102(4 pt 1):1259–1268
GEMA study group. Electrical stimulation for the treatment of gastroparesis: preliminary report of a multicenter international trial. Gastroenterology, 1996,110(5): A668
Chen JD, Qian LW, Ouyang H, et al. Gastric electrical stimulation with short pulses reduces vomiting but not dysrhythmias in dogs. Gastroenterology, 2003,124(4): 401–409
Zhan TT, Qiao X, Liu JS. Effects of short pulse gastric electric stimulation on nerves containing 5-hydroxytryptamine or dynorphin in nucleus of solitary tract of rat. Gastroenterology, 2008,134(4 suppl):S1819
Wen XL, Zhang P, Jiang DS. Comparison of sumianxin and napental on animal anesthesia. J Nanhua University (Chinese), 2004,32(1):131–132
Mejia AA, Nakamura T, Itoh M, et al. Absorbed dose estimates in positron emission tomography studies based on the administration of 18F-labeled radiopharmaceuticals. J Radiat Res, 1991,32(3):243–261
Liu JS, Qiao X, Chen JDZ. Vagal afferent is involved in short-pulse gastric electrical stimulation in rats. Dig Dis Sci, 2004,49(5):729–737
Koch KL, Summy-Long J, Bingaman S, et al. Vasopressin and oxytocin responses to illusory self-motion and nausea in man. J Clin Endocrinol Metab 1990, 71(5):1269–1275
Xu LH, Koch KL, Summy-Long J, et al. Hypothalamic and gastric myoelectrical responses during circular vection-induced nausea in healthy Chinese subjects. Am J Physiol, 1993,265(4 pt 1):E578–584
Fox RA, Keil LC, Daunton NG, et al. Vasopressin and motion sickness in cats. Aviat Space Environ Med, 1987,58(9 pt 2):A143–147
Mitchell A, Collin J. Vasopressin effects on the small intestine: a possible factor in paralytic ileus. Br J Surg, 1985,72(6):462–465
Kelly KA. Pacing the gut. Gastroenterology, 1992, 103(6):1967–1969
Liu JS, Qiao X, Chen JDZ. Therapeutic potentials of a novel method of dual-pulse gastric electrical stimulation for gastric dysrhythmia and symptoms of nausea and vomiting. Am J Surg, 2006,191(2):255–261
Forster J, Sarosiek I, Delcore R, et al. Gastric pacing is a new surgical treatment for gastroparesis. Am J Surg, 2001,182(6):676–681
Tack J, Coulie B, Van Cutsem E. The influence of gastric electrical stimulation on proximal gastric motor and sensory function in severe idiopathic gastroparesis. Gastroenterology, 1999,116(4): G4733
McCallum RW, Dusing RW, Sarosiek I, et al. Mechanisms of high-frequency electrical stimulation of the stomach in gastroparetic patients. Conf Proc IEEE Eng Med Biol Soc, 2006,1:5400–5403
Huang H, Qiao X, Liu JS. Effect of short pulse gastric electrical stimulation on the c-fos expression in the NTS and hypothalamus and its possible mechanism. Chin J Dig (Chinese), 2008,28(11):721–724
Author information
Authors and Affiliations
Additional information
This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30500233).
Rights and permissions
About this article
Cite this article
Xu, B., Qiao, X., Yu, X. et al. Central opioid peptide-containing neurons mediates therapeutic effect of short-pulse gastric electrical stimulation on dyspepsia-like symptoms in dogs. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 701–704 (2009). https://doi.org/10.1007/s11596-009-0605-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11596-009-0605-3