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Insulin resistance in ischemic stroke

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Abstract

Insulin resistance often refers to a pathological condition in which cells fail to respond to the normal actions of insulin. Increasing literature has noted a critical role of insulin resistance in the pathogenesis of ischemic stroke. Insulin resistance plays an important role in the pathogenesis of ischemic stroke via enhancing advanced changes of atherosclerosis. A variety of literature indicates that insulin resistance enhances platelet adhesion, activation and aggregation which are conducive to the occurrence of ischemic stroke. Insulin resistance also induces hemodynamic disturbances and contributes to the onset of ischemic stroke. In addition, insulin resistance may augment the role of the modifiable risk factors in ischemic stroke and induce the occurrence of ischemic stroke. Preclinical and clinical studies have supported that improving insulin resistance may be an effective measure to prevent or delay ischemic stroke.

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Acknowledgments

This work was supported by grants from the Natural Science Foundation of Hubei Province (2015CFB260), and the Hubei Province Health and Family Planning Scientific Research Project (WJ2015MB219) and the Shiyan Natural Science Foundation (15 K70) and Renmin Hospital, Hubei University of Medicine to Dr. Zhiyou Cai.

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  1. Xiao-Ling Deng and Zhou Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, 442000, Hubei Province, People’s Republic of China

    Xiao-Ling Deng

  2. Department of Neurology, The Affiliated Hospital of Guangdong Medical University, and Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong Province, People’s Republic of China

    Zhou Liu

  3. Department of Pathology, Chongqing Medical University, Chongqing, 400016, People’s Republic of China

    Chuanling Wang

  4. Department of Neurology, Peking Union Medical College Hospital, No.1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, People’s Republic of China

    Yanfeng Li

  5. Department of Neurology, Chongqing General Hospital, No. 312 Zhongshan First Road, Yuzhong District, Chongqing, 400013, People’s Republic of China

    Zhiyou Cai

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  1. Xiao-Ling Deng
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Xiao-Ling Deng and Zhou Liu wrote the preliminary draft and revised details of the manuscript. Chuanling Wang contributed to the collection and sorting of the data and documents. Yanfeng Li and Zhiyou Cai revised all manuscript in detail and modified the manuscript.

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Deng, XL., Liu, Z., Wang, C. et al. Insulin resistance in ischemic stroke. Metab Brain Dis 32, 1323–1334 (2017). https://doi.org/10.1007/s11011-017-0050-0

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