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Platelet activity in Chinese obese adolescents with and without insulin resistance

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Abstract

To investigate the platelet activity in Chinese obese adolescents with and without insulin resistance. A cross-sectional study was performed in 159 obese Chinese adolescents to investigate their platelet activity using anthropometrics and biochemical parameters, oral glucose tolerance test and platelet testing. An index of insulin sensitivity, homeostasis model assessment of insulin resistance (HOMA-IR), and plasma fibrinogen, prothrombin fragment 1.2 (PT 1.2), fibrinopeptide A (FPA) and the levels of aggregation to collagen 1 μg/ml, adenosine diphosphate (ADP) 10 μmol/L and arachidonic acid (AA) 0.5 mmol/L were measured. Obese adolescents with insulin resistance had significantly higher HOMA-IR, glucose response curve (AUC), insulin AUC, PT 1.2, FPA and fibrinogen and aggregation (to collagen 1 μg/ml, ADP 10 μmol/L and AA 0.5 mmol/L) comparison with obese adolescents without insulin resistance (P < 0.05). Moreover, a positive correlation was found between both aggregation (to collagen, ADP and AA) and HOMA-IR (ρ = 0.716; P < 0.01, ρ = 0.682; P < 0.01 and ρ = 0.699; P < 0.01, respectively), glucose AUC (ρ = 0.479; P < 0.01, ρ = 0.416; P < 0.01 and ρ = 0.458; P < 0.01, respectively) and insulin AUC (ρ = 0.585; P < 0.01, ρ = 0.511; P < 0.01 and ρ = 0.576; P < 0.01, respectively) in obese adolescents with insulin resistance. Insulin resistance is a major determinant of platelet activation in Chinese obese adolescents.

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Financial disclosure

The present study was funded by the Natural Science Foundation of China (Grant number: 81272820).

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Authors and Affiliations

  1. Business School of Sichuan University/West China Second University Hospital, Sichuan University, No 37 Guoxuexiang/Wuhou District, Chengdu, 610041, Sichuan, China

    Shundong Lei

  2. Regenerative Medicine Research Center, West China Hospital, Sichaun University, Chengdu, 610041, China

    Jiuming Zhao

  3. Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China

    Ni Chen

  4. Department of Hepatobiliopancreatic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China

    Huimin Lu

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  1. Huimin Lu
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  2. Shundong Lei
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  3. Jiuming Zhao
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  4. Ni Chen
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Correspondence to Shundong Lei.

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Lu, H., Lei, S., Zhao, J. et al. Platelet activity in Chinese obese adolescents with and without insulin resistance. J Thromb Thrombolysis 37, 165–170 (2014). https://doi.org/10.1007/s11239-013-0917-9

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