Advertisement

Microchimica Acta

, 186:618 | Cite as

Gold nanoparticle-based detection of dopamine based on fluorescence resonance energy transfer between a 4-(4-dialkylaminostyryl)pyridinium derived fluorophore and citrate-capped gold nanoparticles

  • Juanjuan PengEmail author
  • Na Zhou
  • Yang Zhong
  • Yaoquan Su
  • Lingzhi ZhaoEmail author
  • Young-Tae ChangEmail author
Original Paper
  • 36 Downloads

Abstract

A colorimetric/fluorometric dual-signal assay is described for the determination of dopamine (DA). A nanoprobe was obtained by linking a 4-(4-dialkylaminostyryl)pyridinium derived fluorophore to citrate-capped gold nanoparticles (AuNPs). The fluorescence of the fluorophore is quenched by the AuNPs via fluorescence resonance energy transfe. In the presence of DA, the catechol group of DA can absorb on the surface of AuNPs to induce aggregation, which is accompanied by a color change from red to blue. The yellow fluorescence of the fluorophore with excitation/emission maximum at 365/570 nm is recovered. The dual-signal detection allows the quantitative analysis of DA within 300 μM by the colorimetric method and 80 μM by the fluorometric method. The detection limits for the colorimetric/fluorometric methods are 1.85 μM and 0.29 μM, respectively. Quantitative determination of DA in spiked urine samples was successfully demonstrated, with recoveries ranging from 98.2 to 106.0%.

Graphical abstract

A colorimetric/fluorometric dual-signal assay is described for the determination of dopamine by linking a fluorophore to gold nanoparticles. The dopamine causes aggregation of the nanoparticles to induce color change, which is followed by the recovery of the fluorescence.

Keywords

Dual-signal probe Colorimetry Fluorometry Turn-on Urine samples 

Notes

Acknowledgments

We sincerely acknowledge the financial support of the National Natural Science Foundation of China (81701766 and 81702998).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3727_MOESM1_ESM.docx (2.8 mb)
ESM 1 (DOCX 2.76 mb)

References

  1. 1.
    Rodriguez PC, Pereira DB, Borgkvist A, Wong MY, Barnard C, Sonders MS, Zhang H, Sames D, Sulzer D (2013) Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. P Natl Acad Sci USA 110:870–875CrossRefGoogle Scholar
  2. 2.
    Gingrich JA, Caron MG (1993) Recent advances in the molecular biology of dopamine receptors. Annu Rev Neuro Sci 16:299–321CrossRefGoogle Scholar
  3. 3.
    Ali SR, Ma Y, Parajuli RR, Balogun Y, Lai WYC, He H (2007) A nonoxidative sensor based on a self-doped polyaniline/carbon nanotube composite for sensitive and selective detection of the neurotransmitter dopamine. Anal Chem 79:2583–2587CrossRefGoogle Scholar
  4. 4.
    Merims D, Giladi N (2008) Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat D 14:273–280CrossRefGoogle Scholar
  5. 5.
    Tsai T-C, Huang F-H, Chen J-JJ (2013) Selective detection of dopamine in urine with electrodes modified by gold nanodendrite and anionic self-assembled monolayer. Sensor Actuat B: Chem 181:179–186CrossRefGoogle Scholar
  6. 6.
    Fischbach FT (2000) A manual of laboratory and diagnostic tests (6 ed.) Lippincott Williams & WilkinsGoogle Scholar
  7. 7.
    Chiara GD (1990) In-vivo brain dialysis of neurotransmitters. Trends in Pharmacol Sci 11:116–121CrossRefGoogle Scholar
  8. 8.
    Park YH, Zhang X, Rubakhin SS, Sweedler JV (1999) Independent optimization of capillary electrophoresis separation and native fluorescence detection conditions for indolamine and catecholamine measurements. Anal Chem 71:4997–5002CrossRefGoogle Scholar
  9. 9.
    Syslová K, Rambousek L, Kuzma M, Najmanová V, Bubeníková-Valešová V, Šlamberová R, Kačer P (2011) Monitoring of dopamine and its metabolites in brain microdialysates: method combining freeze-drying with liquid chromatography–tandem mass spectrometry. J Chromatogr A 1218:3382–3391CrossRefGoogle Scholar
  10. 10.
    Lee MH, Kim JS, Sessler JL (2015) Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules. Chem Soc Rev 44:4185–4191CrossRefGoogle Scholar
  11. 11.
    Wu J, Liu W, Ge J, Zhang H, Wang P (2011) New sensing mechanisms for design of fluorescent chemosensors emerging in recent years. Chem Soc Rev 40:3483–3495CrossRefGoogle Scholar
  12. 12.
    Xu J, Yu H, Hu Y, Chen M, Shao S (2016) A gold nanoparticle-based fluorescence sensor for high sensitive and selective detection of thiols in living cells. Biosens Bioelectron 75:1–7CrossRefGoogle Scholar
  13. 13.
    Rawat KA, Bhamore JR, Singhal RK, Kailasa SK (2017) Microwave assisted synthesis of tyrosine protected gold nanoparticles for dual (colorimetric and fluorimetric) detection of spermine and spermidine in biological samples. Biosens Bioelectron 88:71–77CrossRefGoogle Scholar
  14. 14.
    Li N, Zhao P, Astruc D (2014) Anisotropic gold nanoparticles: synthesis, properties, applications, and toxicity. Angew Chem Inter Ed 53:1756–1789CrossRefGoogle Scholar
  15. 15.
    Ahmad R, Griffete N, Lamouri A, Felidj N, Chehimi MM, Mangeney C (2015) Nanocomposites of gold nanoparticles@molecularly imprinted polymers: chemistry, processing, and applications in sensors. Chem Mater 27:5464–5478CrossRefGoogle Scholar
  16. 16.
    Ju J, Chen W (2015) In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments. Anal Chem 87:1903–1910CrossRefGoogle Scholar
  17. 17.
    Sener G, Uzun L, Denizli A (2014) Lysine-promoted colorimetric response of gold nanoparticles: a simple assay for ultrasensitive mercury(II) detection. Anal Chem 86:514–520CrossRefGoogle Scholar
  18. 18.
    Cheng Y-H, Tang H, Jiang J-H (2017) Enzyme mediated assembly of gold nanoparticles for ultrasensitive colorimetric detection of hepatitis C virus antibody. Anal Methods 9:3777–3781CrossRefGoogle Scholar
  19. 19.
    Yu XF, Wang DS, Peng Q, Li YD (2011) High performance electrocatalyst: Pt-Cu hollow nanocrystals. Chem Commun 47:8094–8096CrossRefGoogle Scholar
  20. 20.
    Yu M, Wang H, Fu F, Li L, Li J, Li G, Song Y, Swihart MT, Song E (2017) Dual-recognition Förster resonance energy transfer based platform for one-step sensitive detection of pathogenic bacteria using fluorescent vancomycin–gold nanoclusters and aptamer–gold nanoparticles. Anal Chem 89:4085–4090CrossRefGoogle Scholar
  21. 21.
    Zheng L, Wei J, Lv X, Bi Y, Wu P, Zhang Z, Wang P, Liu R, Jiang J, Cong H, Liang J, Chen W, Cao H, Liu W, Gao GF, Du Y, Jiang X, Li X (2017) Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles. Biosens Bioelectron 91:46–52CrossRefGoogle Scholar
  22. 22.
    Rivero PJ, Ibañez E, Goicoechea J, Urrutia A, Matias IR, Arregui FJ (2017) A self-referenced optical colorimetric sensor based on sil ver and gold nanoparticles for quantitative determination of hydrogen peroxide. Sensor Actuat B: Chem 251:624–631CrossRefGoogle Scholar
  23. 23.
    Shahar T, Sicron T, Mandler D (2017) Nanosphere molecularly imprinted polymers doped with gold nanoparticles for high selectivity molecular sensors. Nano Res 10:1056–1063CrossRefGoogle Scholar
  24. 24.
    Ben Messaoud N, Ghica ME, Dridi C, Ben Ali M, Brett CMA (2017) Electrochemical sensor based on multiwalled carbon nanotube and gold nanoparticle modified electrode for the sensitive detection of bisphenol A. Sensor Actuat B: Chem 253:513–522CrossRefGoogle Scholar
  25. 25.
    Kanayama N, Takarada T, Maeda M (2011) Rapid naked-eye detection of mercury ions based on non-crosslinking aggregation of double-stranded DNA-carrying gold nanoparticles. Chem Commun 47:2077–2079CrossRefGoogle Scholar
  26. 26.
    Cao R, Li B, Zhang Y, Zhang Z (2011) Naked-eye sensitive detection of nuclease activity using positively-charged gold nanoparticles as colorimetric probes. Chem Commun 47:12301–12303CrossRefGoogle Scholar
  27. 27.
    Chen S-J, Chang H-T (2004) Nile red-adsorbed gold nanoparticles for selective determination of thiols based on energy transfer and aggregation. Anal Chem 76:3727–3734CrossRefGoogle Scholar
  28. 28.
    Lo S-H, Wu M-C, Wu S-P (2015) A turn-on fluorescent sensor for cysteine based on BODIPY functionalized Au nanoparticles and its application in living cell imaging. Sensor Actuat B: Chem 221:366–1371CrossRefGoogle Scholar
  29. 29.
    He X, Liu H, Li Y, Wang S, Li Y, Wang N, Xiao J, Xu X, Zhu D (2005) Gold nanoparticle-based fluorometric and colorimetric sensing of copper(II) ions. Adv Mater 17:2811–2815CrossRefGoogle Scholar
  30. 30.
    Ipe BI, Yoosaf K, Thomas KG (2006) Functionalized gold nanoparticles as phosphorescent nanomaterials and sensors. J Am Chem Soc 128:1907–1913CrossRefGoogle Scholar
  31. 31.
    Huang C-C, Chang H-T (2006) Selective gold-nanoparticle-based "turn-on" fluorescent sensors for detection of mercury(II) in aqueous solution. Anal Chem 78:8332–8338CrossRefGoogle Scholar
  32. 32.
    Zhang N, Liu Y, Tong L, Xu K, Zhuo L, Tang B (2008) A novel assembly of Au NPs–β-CDs–FL for the fluorescent probing of cholesterol and its application in blood serum. Analyst 133:1176–1181CrossRefGoogle Scholar
  33. 33.
    Lin Y, Chen C, Wang C, Pu F, Ren J, Qu X (2011) Silver nanoprobe for sensitive and selective colorimetric detection of dopaminevia robust Ag-catechol interaction. Chem Commun 47:1181–1183CrossRefGoogle Scholar
  34. 34.
    Stöber W, Fink A, Bohn E (1968) Controlled growth of monodisperse silica spheres in the micron size range. J Colloid Inter Sci 26:62–69CrossRefGoogle Scholar
  35. 35.
    Li JF, Huang YF, Ding Y, Yang ZL, Li SB, Zhou XS, Fan FR, Zhang W, Zhou ZY, Wu DY, Ren B, Wang ZL, Tian ZQ (2010) Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature 464:392–395CrossRefGoogle Scholar
  36. 36.
    Chen J, Li Y, Huang Y, Zhang H, Chen X, Qiu H (2019) Fluorometric dopamine assay based on an energy transfer system composed of aptamer-functionalized MoS2 quantum dots and MoS2 nanosheets. Microchim Acta 186:58CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical PharmacyChina Pharmaceutical UniversityNanjingChina
  2. 2.School of Materials Science and Engineering, Hebei Provincial Key Laboratory of Traffic Engineering MaterialsShijiazhuang Tiedao UniversityShijiazhuangChina
  3. 3.Center for Self-assembly and ComplexityInstitute for Basic Science (IBS)PohangSouth Korea
  4. 4.Department of ChemistryPohang University of Science and TechnologyPohangSouth Korea

Personalised recommendations