Relationship between episodic memory and volume of the brain regions of two functional cortical memory systems in multiple sclerosis
Two functional networks are proposed as neuronal support for the complex processes of memory: the anterior temporal and the medial posterior systems. We examined the atrophy of hippocampus (HC) and of those areas constituting the two functional memory systems in multiple sclerosis (MS) patients with low disability.
Episodic memory (EM) was assessed in 88 relapsing MS patients and in 40 healthy controls using Wechsler Memory Scale III (Spanish adaptation). FreeSurfer software was used to calculate normalized volume of total cortex, grey matter, white matter, subcortical grey matter (thalamus and striatum), HC and both the anterior temporal (entorhinal, ventral temporopolar, lateral orbitofrontal, amygdala) and posterior medial systems (thalamus, parahippocampal, posterior cingulate, precuneus, lateral parietal and medial prefrontal). Linear regression analysis was used to identify predictors of memory performance.
Total grey matter and cortex volumes correlated with all subtypes of EM, and the precuneus volume correlated with overall, immediate and delayed memories. Univariant regression analysis identified an association between the volumes of the posterior medial memory network regions and EM scores. The volume of the left precuneus area was the unique and independent predictor for all EM subtypes except for visual memory, for which left HC volume was also an independent predictor.
Left precuneus volume was the best predictor of memory in relapsing MS patients with low disability and mild deficits in EM.
KeywordsMultiple sclerosis Episodic memory Volumetric MRI Functional memory systems Precuneus Hippocampus
The authors are grateful to MS patients and HC for their participation.
This research was supported by Novartis.
Compliance with ethical standards
Conflicts of interest
Authors declare not having conflicts of interest with respect to this work. We report all possible disclosures to be thorough. Y. A. had received speakers’ honoraria from Novartis, Biogen Idec, Teva and Merck Serono; serves as a consultant and scientific advisory board for some Pharmaceutical Industries (Teva, Novartis, Biogen Idec, Sanofi Genzyme and Merck Serono). M. C. received support to investigate from Novartis and Teva.
All procedures performed in this study involving human participants were carried out respecting the principles established in the 1964 Helsinki Declaration and its later amendments, the requirements by the Spanish legislation on biomedical investigation and protection of personal data.
- 4.Travis SG, Huang Y, Fujiwara E et al (2014) High field structural MRI reveals specific episodic memory correlates in the subfields of the hippocampus. Neuropsychologia 53:233–245. https://doi.org/10.1016/j.neuropsychologia.2013.11.016 CrossRefPubMedGoogle Scholar
- 17.Wechsler D (2004) Wechsler Memory Scale, 3rd edn. TEA Ediciones, MadridGoogle Scholar
- 32.Bailly M, Destrieux C, Hommet C et al (2015) Precuneus and cingulate cortex atrophy and hypometabolism in patients with Alzheimer’s disease and mild cognitive impairment: MRI and F-18-FDG PET quantitative analysis using freesurfer. Biomed Res Int. https://doi.org/10.1155/2015/583931 PubMedPubMedCentralCrossRefGoogle Scholar