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Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria

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Abstract

Non-alcoholic fatty-liver disease (NAFLD) is now considered one of the leading causes of liver disease worldwide and is associated with metabolic syndrome and obesity. There are several factors contributing to the disease state. Recent research suggests that the intestinal microbiota (IM) and bacterial products may play a role through several mechanisms which include increased energy uptake, intestinal permeability and chronic inflammation. In addition to diet and exercise, treatment options targeting the IM are being investigated and include the use of pre-, pro- and synbiotics as well as the possibility of fecal microbial transfers. This literature review explores the relationship between NAFLD and the IM as well as highlight new IM treatment options that may become available in the near future.

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Authors and Affiliations

  1. Institute of Medical Science, University of Toronto, Toronto, ON, Canada

    Katherine J. P. Schwenger

  2. Toronto General Hospital, University Health Network, 585 University Avenue, 9-973, Toronto, ON, M5G 2C4, Canada

    Katherine J. P. Schwenger, Colin M. Bolzon, Carrie Li & Johane P. Allard

  3. Department of Medicine, University of Toronto, Toronto, Canada

    Johane P. Allard

  4. Department of Nutritional Sciences, University of Toronto, Toronto, Canada

    Johane P. Allard

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Schwenger, K.J.P., Bolzon, C., Li, C. et al. Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria. Eur J Nutr 58, 1771–1784 (2019). https://doi.org/10.1007/s00394-018-1844-5

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