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Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T

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References

  1. Pedersen RS, Damkier P, Brosen K (2006) Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers. Eur J Clin Pharmacol 62:513–521

    Article  PubMed  CAS  Google Scholar 

  2. Wang G, Zhang H, He F, Fang X (2006) Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population. Eur J Clin Pharmacol 62:927–931

    Article  PubMed  CAS  Google Scholar 

  3. Wu WN, McKown LA, Liao S (2002) Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites. Xenobiotica 32:411–425

    Article  PubMed  CAS  Google Scholar 

  4. Poulsen L, Arendt-Nielsen L, Brosen K, Sindrup SH (1996) The hypoalgesic effect of tramadol in relation to CYP2D6. Clin Pharmacol Ther 60:636–644

    Article  PubMed  CAS  Google Scholar 

  5. Gleason PP, Frye RF, O’Toole T (1997) Debilitating reaction following the initial dose of tramadol. Ann Pharmacother 31:1150–1152

    PubMed  CAS  Google Scholar 

  6. Enggaard TP, Poulsen L, Arendt-Nielsen L, Brosen K, Ossig J, Sindrup SH (2006) The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6. Anesth Analg 102:146–150

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Clinical Pharmacology Unit, Institute of Pharmacology, 1st Faculty of Medicine, Charles University, Na Bojišti 1, Praha 2, 120 00, Czech Republic

    Ondřej Slanař, Olga Matoušková, Jeffrey R. Idle & František Perlík

  2. Institute of Experimental Biopharmaceutics, Joint Research Center of Academy of Sciences of the Czech Republic and PRO.MED.CS Praha a.s., Heyrovského 1207, Hradec Králové, 500 03, Czech Republic

    Milan Nobilis & Jaroslav Kvétina

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  1. Ondřej Slanař
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  2. Milan Nobilis
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  3. Jaroslav Kvétina
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  4. Olga Matoušková
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  5. Jeffrey R. Idle
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  6. František Perlík
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Correspondence to Ondřej Slanař.

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Slanař, O., Nobilis, M., Kvétina, J. et al. Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T . Eur J Clin Pharmacol 63, 419–421 (2007). https://doi.org/10.1007/s00228-006-0255-3

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  • DOI: https://doi.org/10.1007/s00228-006-0255-3

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