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Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population

  • Pharmacogenetics
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Objective

The CYP2D6*10 allele is the most common allele with a frequency ranging from 51.3 to 70% and correlated with a significantly reduced metabolic activity in a Chinese population. The aim of the present study was to investigate whether the CYP2D6*10 allele has an impact on the postoperative analgesia effect of tramadol in Chinese patients recovering from major abdominal surgery.

Methods

A prospective study design was used and 70 gastric cancer patients recovering from gastrectomy were enrolled. After receiving a loading dose i.v., patients could self-administer doses of the drug combination (10 mg/ml tramadol plus 0.3 mg/ml metoclopramide) via patient-controlled analgesia (PCA). Blood samples were collected after induction of anesthesia. The CYP2D6*10 C188T polymorphism was analyzed by means of polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Demographic data among groups with different genotypes were analyzed using analysis of variance. The total consumption of tramadol between the three genotype groups for 48 h was compared.

Results

The allele frequency of CYP2D6*10 is 52.4%; patients were categorized into three groups according to the CYP2D6 genotype: patients without CYP2D6*10 (group I, n=17), patients heterozygous for CYP2D6*10 (group II, n=26), and patients homozygous for CYP2D6*10 (group III, n=20). The demographic data among the three groups were comparable. The total consumption of tramadol for 48 h in group III was significantly higher than that in groups I and II, while it did not differ between groups I and II.

Conclusions

This study indicates that the CYP2D6*10 allele has significant impact on analgesia with tramadol in a Chinese population. Pharmacogenetics may explain some of the varying responses to pain medication in postoperative patients.

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Acknowledgements

We would like to thank Ingolf Cascorbi (MD, PhD, Professor and Chair of Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany) for his serious editing and rewriting of the discussion part of this manuscript, and thank Frank Stuber (MD, PhD, Professor of Anaesthesiology, Bonn University, Germany) and Ulrike Stamer (MD, PhD, Associate Professor of Anaesthesiology, Bonn University, Germany) for their help in designing this study. This study was supported by the National Natural Science Foundation of China (No. 30471662/C03030301). GX Wang and H Zhang contributed comparably to this study.

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Authors and Affiliations

  1. Department of Anaesthesiology, First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79, Qing Chun Road Hangzhou, Zhejiang, 310003, China

    GuoXiang Wang, FeiFang He & XiangMing Fang

  2. Department of Anaesthesiology, Hangzhou Red Cross Hospital, Hangzhou, China

    GuoXiang Wang

  3. Department of Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Hui Zhang

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  1. GuoXiang Wang
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  2. Hui Zhang
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  4. XiangMing Fang
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Corresponding author

Correspondence to XiangMing Fang.

Additional information

GX Wang and H Zhang contributed comparably to this study.

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Wang, G., Zhang, H., He, F. et al. Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population. Eur J Clin Pharmacol 62, 927–931 (2006). https://doi.org/10.1007/s00228-006-0191-2

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  • DOI: https://doi.org/10.1007/s00228-006-0191-2

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