Synthesis of NSAIDs–Se derivatives as potent anticancer agents
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In the present study, a series of NSAIDs–Se derivatives include selenocyanates and diselenides were synthesized and characterized, their anticancer activities against the human cancer cell lines SW480, HeLa, A549, and HepG2 were determined. Interestingly, most of the new compounds showed active in reducing the viability of different cancer lines. Compounds 1a and 1m exhibited higher promising activities than other derivatives. As the most active compound 1a showed IC50 values lower than 20 μM against the four cancer cell lines, particularly against SW480 with IC50 values below 10 μm, it shows the potential to be a promising molecular chemotherapeutic agent for colorectal cancer.
KeywordsSelenocyanates Diselenides NSAIDs Anticaner
This investigation was made possible through the financial support of National Natural Science Foundation of China (Grant No: 21302065).
Compliance with ethical standards
Conflict of interest
We declare that we have no financial and personal relationships with other people or organizations that caninappropriately influence our work, there is no professional or other personal interest of any nature or kind inany product, service and/or company that could be construed as influencing the position presented in, or thereview of, the manuscript entitled “Synthesis of NSAIDs–Se derivatives as potent anticancer agents”.
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