Abstract
In search of pharmalogically active molecules in the class of oxadiazoles, the present article deals with the synthesis of 5-(5′-fluoro-2′-methoxybiphenyl-3-yl)-1,3,4-oxadiazol-2(3H)-one 2 from its hydrazide analog 1. The compound 2 was regioselectively N-alkylated with alkyl halides and produced the compounds 3a–f. Compound 3f was further functionalized with substituted benzenesulfonyl chlorides to give compounds 3g–j. The synthesized compounds were characterized by elemental and spectral analysis. Newly synthesized compounds were tested for their in vivo anti-inflammatory, analgesic, and in vitro antimicrobial activities. The compounds 3a–c were found to have promising anti-inflammatory and analgesic activities. Compounds 3b, 3f, and 3g showed significant antibacterial and antifungal activities.
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Acknowledgments
The authors are thankful to the Head of Syngene International Ltd. for laboratory facilities. The authors are also thankful to Dr. Ashis Baran Mandal, Drs. Sandipan Sarkar, Sateesh Rai, and Prashanth Latte for their valuable support.
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Ramaprasad, G.C., Kalluraya, B., Sunil Kumar, B. et al. Synthesis of new oxadiazole derivatives as anti-inflammatory, analgesic, and antimicrobial agents. Med Chem Res 22, 5381–5389 (2013). https://doi.org/10.1007/s00044-012-0298-1
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DOI: https://doi.org/10.1007/s00044-012-0298-1