Summary
Temporal development of radicular demyelination was studied in male albino rats examined sequentially throughout the lifespan of the animals. The rats were perfusion-fixed with paraformaldehyde and glutaraldehyde and areas of their nervous system including the lumbar spinal roots, the spinal cord, and the peripheral sciatic nerve, were embedded in epoxy resin and submitted to microscopic examination in semithin and ultrathin sections. In addition, a vital fat stain, teasing of single nerve fibers, and estimates of axon diamter and fiber number were obtained. Degenerative changes occurred earlier in the distal portions of nerve fibers than in the spinal roots. The radicular lesion consisted of swelling of myelin and demyelination possibly secondary to shrinkage of axons, resulting in focal accumulation of lipid debris within the spinal roots of old rats. Although the causation of senile neuronal atrophy affecting rat peripheral neurons is not fully obvious, this condition may be exacerbated by such factors as pressure on the nerves and hypoactivity.
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References
Burek JD (1978) Pathology of aging rats. CRC Press, West Palm Beach, FL
Cammer W, Rose AL, Norton WT (1975) Biochemical and pathological studies of myelin in hexachlorophene intoxication. Brain Res 98:547–559
Carlson J, Lais AC, Dyck PJ (1979) Axonal atrophy from permanent peripheral axotomy in adult cat. J Neuropathol Exp Neurol 38:579–585
Duncan D (1934) A determination of the number of nerve fibres in the eighth thoracic and the largest lumbar ventral roots of the albino rat. J Comp Neurol 59:47–60
Dunn EH (1912) The influence of age, sex, weight, and relationship upon the number of medullated nerve fibres and on the size of the largest fibres in the ventral root of the second cervical nerve of the albino rat. J Comp Neurol 22:131–157
Dyck PJ (1975) Pathologic alterations of the peripheral nervous system of man. In: Dyck PJ, Thomas PK, Lambert EH (eds) Peripheral neuropathy I. Saunders, Philadelphia London Toronto, pp 296–336
Eisen AA, Carpenter S, Karpati G, Bellavance A (1973) The effect of muscle hyper- and hypoactivity upon fibre diameters of intact and regenerating nerves. J Neurol Sci 20:457–469
Friede RL, Bischhausen R (1982) How are sheath dimensions affected by axon caliber and internode length? Brain Res 235:335–350
Fujisawa K, Shiraki H (1980) Study of axonal dystrophy. II. Dystrophy and atrophy of the presynaptic boutons: A dual pathology. Neuropathol Appl Neurobiol 6:387–398
Grover-Johnson N, Spencer PS (1981) Peripheral nerve abnormalities in aging rats. J Neuropathol Exp Neurol 40:155–165
Hofteig JH, Vo PN, Yates AJ (1981) Wallerian degeneration of peripheral nerve. Age-dependent loss of nerve lipids. Acta Neuropathol (Berl) 55:151–156
King RHM, Thomas PK (1982) Ultrastructural changes in peripheral nerve with aging. 9th Meeting of Swiss Neuropathologists (with International Participation), St. Moritz, Switzerland
Krinke G, Suter J, Hess R (1981) Radicular myelinopathy in aging rats. Vet Pathol 18:335–341
Lubińska L (1961) Demyelination and remyelination in the proximal parts of regenerating nerve fibres. J Comp Neurol 117:275–289
Mitsumori K, Maita K, Shirasu Y (1981) An ultrastructural study of spinal nerve roots and dorsal root ganglia in aging rats with spontaneous radiculoneuropathy. Vet Pathol 18:714–726
Moore SA, Peterson RG, Felten DL, O'Connor BL (1981) Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats. J Neurol Sci 52:289–303
Ochoa J, Fowler TJ, Gilliatt RW (1972) Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat 113:433–455
Spencer PS, Thomas PK (1970) The examination of isolated nerve fibres by light and electron microscopy, with observations on demyelination proximal to neuromas. Acta Neuropathol (Berl) 16:177–186
Spoerri PE, Gless P, Spoerri O, (1981) Neuronal regression during aging: An ultrastructural study of the human cortex. J Hirn-forsch 22:441–446
Thomas PK (1974) Nerve injury. In: Bellairs R, Gray EG (eds) Essays on the nervous system. Clarendon Press, Oxford, pp 44–70
Thomas PK, King RHM, Sharma AK (1980) Changes with age in the peripheral nerves of the rat. An ultrastructural study. Acta Neuropathol (Berl) 52:1–6
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Krinke, G. Spinal radiculoneuropathy in aging rats: Demyelination secondary to neuronal dwindling?. Acta Neuropathol 59, 63–69 (1983). https://doi.org/10.1007/BF00690318
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DOI: https://doi.org/10.1007/BF00690318