Abstract
Rats received haloperidol (1.3–1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the density of D2 receptors in the striatum by 70% and in the medial prefrontal cortex by 50%. The chronic haloperidol did not significantly alter the apparent affinity of D2 receptors for [3H]-spiperone in either structure. These results indicate that the density of D2 receptors in the medial prefrontal cortex is influenced by chronic exposure to haloperidol in a manner that is very similar to the well-documented increase that occurs in the striatum.
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References
Bacopoulos NC, Spokes EG, Bird ED, Roth RH (1979) Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment. Science 205:1405–1407
Bannon MJ, Roth RH (1983) Pharmacology of mesocortical dopamine neurons. Pharmacol Rev 35:53–68
Bowers MB, Hoffman FJ, (1984) Homovanillic acid in rat caudate and prefrontal cortex following phencyclidine and amphetamine. Psychopharmacology 84:136–137
Griffith JD, Cavanaugh JH, Held J, Oates JA (1970) Experimental psychosis induced by the administration of d-amphetamine. In: Costa E, Garattini S (eds) Amphetamines and related compounds. Raven Press, New York, pp 897–904
Mackay AVP, Iversen LL, Rossor M, Spokes E, Bird E, Arregui A, Creese I, Snyder SH (1982) Increased brain dopancine and dopancine receptors in schizophrenia. Arch Gen Psychiatry 39:991–997
Matsumoto T, Uchimura H, Hirano M, Kim JS, Yokoo H, Shimomura M, Nakahara T, Inoue K, Oomagari K (1983) Differential effects of acute and chronic administration of haloperidol on homovanillic acid levels in discrete dopaminergic areas of rat brain. Eur J Pharmacol 89:27–33
Meller E, Bohmaker K, Rosengarten H, Friedhoff AJ (1982) Chronic haloperidol does not increase specific dopamine receptor binding in rat frontal cortex. Res Commun Chem Pathol Pharmacol 37:323–332
Owen F, Cross AJ, Waddington JL, Poulter M, Gamble SJ, Crow TJ (1980) Dopamine-related behavior and [3H]-spiperone binding to striatal membranes in rats after nine months haloperidol administration. Life Sci 26:55–59
Reynolds GP, Riederer P, Jellinger K, Gabriel E (1981) Dopamine receptors and schizophrenia: the neuroleptic drug problem. Neuropharmacology 20:1319–1320
Robinson TE, Becker JB, Moore CJ, Castaneda E, Mittleman G (1985) Enduring enhancement in frontal cortex dopamine utilization in an animal model of amphetamine psychosis. Brain Res 343:374–377
Seeman P (1981) Brain dopamine receptors. Pharmacol Rev 32:229–313
Snyder SH (1980) Phencyclidine. Nature 285:355–356
Thierry A-M, Tassin J-P, Glowinski J (1984) Biochemical and electrophysiological studies of the mesocortical dopamine system. In: Descarries L, Reader TR, Jasper HH (eds) Monoamine innervation of cerebral cortex. Liss, New York, pp 233–261
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MacLennan, A.J., Atmadja, S., Lee, N. et al. Chronic haloperidol administration increases the density of D2 dopamine receptors in the medial prefrontal cortex of the rat. Psychopharmacology 95, 255–257 (1988). https://doi.org/10.1007/BF00174519
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DOI: https://doi.org/10.1007/BF00174519