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Effects of T-lymphocytes and interferon-γ on different stages of development of multicellular tumor spheroids in vitro

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Abstract

The effect of T lymphocytes and interferon-γ on the vital activity of breast cancer cell population and the formation of multicellular tumor spheroids was studied. The stages of multicellular tumor spheroid formation and the possible ways for realizing the antitumor effects of T lymphocytes and interferon-γ through changes in the expression of estrogen receptors were demonstrated. The results have shown a correlation between the type of humoral effects and the level of expression of estrogen receptor and epidermal growth factor receptor and the intensity of tumor microaggregate formation.

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Authors and Affiliations

  1. Department of Biotechnical Problems of Diagnostics, Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, pr. Nauki 42/1, Kyiv, 03028, Ukraine

    O. Perepelytsina, T. Gergeliuk & M. Sydorenko

Authors
  1. O. Perepelytsina
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  2. T. Gergeliuk
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  3. M. Sydorenko
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Correspondence to O. Perepelytsina.

Additional information

Original Russian Text © O. Perepelytsina, T. Gergeliuk, M. Sydorenko, 2014, published in Tsitologiya i Genetika, 2014, Vol. 48, No. 5, pp. 18–26.

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Perepelytsina, O., Gergeliuk, T. & Sydorenko, M. Effects of T-lymphocytes and interferon-γ on different stages of development of multicellular tumor spheroids in vitro. Cytol. Genet. 48, 285–292 (2014). https://doi.org/10.3103/S0095452714050065

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