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Development and Evaluation of HILIC-type Sorbents Modified with Hydrophilic Copolymers for Solid-phase Extraction

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Abstract

Hydrophilic interaction chromatography (HILIC) has attractive attention for the separation of water-soluble compounds via HPLC. There are, however, few studies on the pretreatment of the HILIC-type solid-phase extraction (SPE) due to the difficulty of obtaining the HILIC-type sorbent. Therefore, the development of HILIC-type sorbents for SPE is essential. In this study, four different hydrophilic copolymers, namely diallylamine-maleic acid copolymer (DAM), diallylamine-acrylamide copolymer (DAA), allylamine-maleic acid copolymer (MAM), and partly methylcarbonylated allylamine acetate copolymer (MAC), were immobilized on glycidyl methacrylate (GMA)-base resin, and their adsorptive properties were evaluated. The results of the physical and adsorptive properties indicated that a balance between the water content of the water-enriched layer on sorbent and the amount of hydrophilic copolymer immobilized on the GMA-base resin was vital for the adsorption in HILIC-type sorbent for SPE.

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Authors and Affiliations

  1. Department of Applied Chemistry, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, 470-0392, Japan

    Hiroya Murakami, Takuya Sugiyama, Yuta Miki, Yoshinori Inoue & Norio Teshima

  2. School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, 192-0392, Japan

    Tomonari Umemura

  3. Gifu Pharmaceutical University, Daigaku-nishi, Gifu, 501-1196, Japan

    Yukihiro Esaka

Authors
  1. Hiroya Murakami
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  2. Takuya Sugiyama
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  3. Yuta Miki
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  4. Tomonari Umemura
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  5. Yukihiro Esaka
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  6. Yoshinori Inoue
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  7. Norio Teshima
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Correspondence to Hiroya Murakami.

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Murakami, H., Sugiyama, T., Miki, Y. et al. Development and Evaluation of HILIC-type Sorbents Modified with Hydrophilic Copolymers for Solid-phase Extraction. ANAL. SCI. 36, 1185–1189 (2020). https://doi.org/10.2116/analsci.20P084

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  • DOI: https://doi.org/10.2116/analsci.20P084

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