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Photothermally modulated drug release kinetics for pH and thermo-responsive hydrogel system

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Abstract

Injectable hydrogel systems to achieve controlled drug release for localized chemotherapy are emerging modality for cancer therapy. Here, an injectable hydrogel system for in situ gelation based on tumor physiological conditions, incorporated with photothermal agent is investigated for photothermally modulated drug release. Gelation of poly(acrylic acid) and Pluronic F127 incorporated with silica-coated gold nanorods and methotrexate (MTX), is tuned to occur within five minutes at 37 °C and pH values of 5 or 7.4. The hydrogel is photothermally stable for repeated irradiation and the photothermal response shows ~ 24 °C temperature rise. On irradiation for three consecutive ON/OFF cycles, controlled MTX release of ~ 42.5% at pH 5.0, and ~ 29% at pH 7.4 was demonstrated. MTX release kinetics revealed non-Fickian diffusion along with matrix erosion and polymer relaxation mechanism. Hydrogel system provides photothermally modulated controlled anti-cancer drug release wherein the gelation and drug release can be tuned for tumor physiology.

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No datasets were created or analyzed in the current study, so data sharing is not applicable to this article.

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Acknowledgments

RG acknowledges ICMR fellowship wide no. 5/3/8/37/ITR-F/2020 for providing financial support. Authors acknowledge CSIR-Central Scientific Instruments Organisation, Chandigarh, India and Amity University Punjab, Mohali for providing infrastructure support.

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No funding was received.

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Authors and Affiliations

  1. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

    Rizul Gautam & Sanjeev Soni

  2. Biomedical Applications Group, CSIR—Central Scientific Instruments Organisation, Sector-30 C, Chandigarh, 160030, India

    Rizul Gautam & Sanjeev Soni

  3. Department of Biotechnology, Amity University Punjab, Mohali, 140306, India

    Ishita Matai

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  1. Rizul Gautam
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  2. Ishita Matai
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Contributions

RG: Conceptualization, Methodology, Formal analysis, and investigation, Writing—original draft and preparation. IM: Methodology, Formal analysis and investigation, Writing—review and editing, Supervision. SS: Methodology, Formal analysis and investigation, Writing-—original draft and preparation, Supervision, Resources.

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Correspondence to Sanjeev Soni.

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Gautam, R., Matai, I. & Soni, S. Photothermally modulated drug release kinetics for pH and thermo-responsive hydrogel system. Journal of Materials Research 39, 398–411 (2024). https://doi.org/10.1557/s43578-023-01233-0

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