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Application of Solvent Parameters for Predicting Organogel Formation

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Abstract

Solvents, accounting the majority of the organogel system, have a tremendous impact on the characteristics of gels. To date, there is a large variety of organogel systems; relatively few have been investigated in the field of structure-solvent correlation. Here, a series of solvent parameters were applied to explore the role of solvent effect on network forming and gel property, intending to build the connection between the precise solvent parameter and gel property. Among the solvent parameters, Kamlet–Taft Parameters and Hansen solubility parameters can distinguish specific types of intermolecular interactions, which could correlate solvent parameter with the gel property. From an analysis of the morphologies obtained from POM and SEM, the gelator structure has an impact on its self-assembly. For possible conformations, the gelators were investigated through XRD. The investigation of solvent-property relationship will provide a theoretical basis for controllable drug delivery implants.

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Funding

This work was supported by National Natural Science Foundation of China under Grant No. 81273445.

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Authors and Affiliations

  1. School of Pharmacy, Shenyang Pharmaceutical University, 85 Hongliu Road, Benxi, 117004, People’s Republic of China

    Beibei Hu, Wei Sun, Baixue Yang, Heran Li, Liuchenzi Zhou & Sanming Li

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  1. Beibei Hu
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  2. Wei Sun
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  3. Baixue Yang
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  4. Heran Li
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  5. Liuchenzi Zhou
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  6. Sanming Li
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Correspondence to Sanming Li.

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Hu, B., Sun, W., Yang, B. et al. Application of Solvent Parameters for Predicting Organogel Formation. AAPS PharmSciTech 19, 2288–2300 (2018). https://doi.org/10.1208/s12249-018-1074-4

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  • DOI: https://doi.org/10.1208/s12249-018-1074-4

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