Abstract
Skin aging is an current problem of modern geriatric cosmetology. One promising method to decelerate the process of age-related skin changes is the use of cosmetics with short peptides. The goal of the work was to study the effect of peptide KE (Lys-Glu, Vilon) on the expression of aging markers of human fibroblasts in an in vitro model. The expression of collagen type 1 and sirtuin 6 was studied with immunofluorescent confocal microscopy in “young” and “old” cultures of skin fibroblasts. It has been found that the area of expression of collagen type 1 and sirtuin 6 decreases by 3.5 and 3.6 times, respectively, in skin fibroblast cultures with aging. Peptide KE increases the expression area of collagen type 1 in old skin fibroblast cultures by 83%; the expression area of sirtuin 6 in young and old cultures of skin fibroblasts increased by 1.6 and 2.6 times, respectively. Thus, peptide KE increases the functional activity of skin fibroblasts and decelerates their senescence.
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Fridman, N.V., Linkova, N.S., Polyakova, V.O. et al. Molecular Aspects of the Geroprotective Effect of Peptide KE in Human Skin Fibroblasts. Adv Gerontol 8, 235–238 (2018). https://doi.org/10.1134/S2079057018030050
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DOI: https://doi.org/10.1134/S2079057018030050