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Short peptides stimulate cell regeneration in skin during aging

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Abstract

The search for new safe and efficient low-molecular weight substances stimulating skin regeneration is an important objective of geriatric cosmetology. The present study addressed the effects of the peptides LK and AEDG at concentrations of 0.05–2.00 ng/mL on the proliferation of organotypic tissue cultures of skin from young and old animals. The application of peptides enhanced fibroblast proliferation in skin cell cultures from young and old animals by 29–45%. The effect on aging skin was observed in a narrower concentration range; in addition, it was less pronounced than the effect on skin cell cultures obtained from young animals. These data reveal the potential of LK and AEDG as components of cosmetic products that restore the structure of aging skin.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    N. I. Chalisova, A. N. Zhekalov & V. Kh. Khavinson

  2. St. Petersburg Institute of Bioregulation and Gerontology, pr. Dinamo 3, St. Petersburg, 197110, Russia

    N. S. Linkova, A. O. Orlova, G. A. Ryzhak & V. Kh. Khavinson

  3. St. Petersburg State Polytechnical University, ul. Polytekhnicheskaya 29, St. Petersburg, 195251, Russia

    N. S. Linkova

  4. Mechnikov State Medical University of Northwestern Russia, ul. Kirochnaya 41, St. Petersburg, 193015, Russia

    V. Kh. Khavinson

Authors
  1. N. I. Chalisova
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  2. N. S. Linkova
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  3. A. N. Zhekalov
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  4. A. O. Orlova
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  5. G. A. Ryzhak
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  6. V. Kh. Khavinson
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Corresponding author

Correspondence to N. S. Linkova.

Additional information

Original Russian Text © N.I. Chalisova, N.S. Linkova, A.N. Zhekalov, A.O. Orlova, G.A. Ryzhak, V.Kh. Khavinson, 2014, published in Uspekhi Gerontologii, 2014, Vol. 27, No. 4, pp. 699–703.

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Chalisova, N.I., Linkova, N.S., Zhekalov, A.N. et al. Short peptides stimulate cell regeneration in skin during aging. Adv Gerontol 5, 176–179 (2015). https://doi.org/10.1134/S2079057015030054

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  • DOI: https://doi.org/10.1134/S2079057015030054

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