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The role of vascular endothelial growth factor in the regulation of development and functioning of the brain: New target molecules for pharmacotherapy

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Abstract

There is evidence that members of the VEGF family are involved in the crucial processes in the brain: atherosclerosis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair. Most of these effects are mediated by VEGF-A and the VEGFR-2 receptor. VEGF signaling pathways contain some potential targets relevant for pharmacological agents applicable for therapy of neurological diseases affecting the brain.

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Authors and Affiliations

  1. Voyno-Yasenetski Krasnoyarsk State Medical University, ul. Partizana Zheleznyaka 1, Krasnoyarsk, 660000, Russia

    V. V. Roslavtceva, A. B. Salmina & S. V. Prokopenko

  2. Berzon Krasnoyarsk Regional Clinical Hospital no. 20, Krasnoyarsk, 660014, Russia

    E. A. Pozhilenkova, I. V. Kobanenko & G. G. Rezvitskaya

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  1. V. V. Roslavtceva
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Original Russian Text © V.V. Roslavtceva, A.B. Salmina, S.V. Prokopenko, E.A. Pozhilenkova, I.V. Kobanenko, G.G. Rezvitskaya, 2016, published in Biomeditsinskaya Khimiya.

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Roslavtceva, V.V., Salmina, A.B., Prokopenko, S.V. et al. The role of vascular endothelial growth factor in the regulation of development and functioning of the brain: New target molecules for pharmacotherapy. Biochem. Moscow Suppl. Ser. B 10, 300–309 (2016). https://doi.org/10.1134/S1990750816040053

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