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Design, Synthesis, and In Vitro Cytotoxic Activity of Certain 2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl]acetamide Derivatives

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Abstract

With a view to finding new anticancer agents, different aryloxy groups were attached to C2 of the pyrimidine ring in 2-[3-phenyl-4-(pyrimidin-4-yl)-1H-pyrazol-1-yl]acetamide in five steps using methyl 3-methoxy-5-methylbenzoate as the key intermediate product. The anticancer activity of the synthesized compounds was tested on 60 cancer cell lines at 10 µM. One compound showed an appreciable cancer cell growth inhibition (about 20%) against eight cancer cell lines (HOP-92, NCI-H226, 79SNB-75, A498, SN12C, UO-31, T-47D, and MDA-MB-468).

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Funding

This research was supported by the Jouf University (grant no. 40/150) and by Korea Institute of Science and Technology (2019 KIST School partnership project).

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, 2014, Sakaka, Saudi Arabia

    M. M. Al-Sanea, D. G. T. Parambi, R. B. Bakr, M. Gamal & M. A. Abdelgawad

  2. Department of Pharmacology, College of Pharmacy, Jouf University, 2014, Sakaka, Saudi Arabia

    M. E. Shaker

  3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt

    M. E. Shaker

  4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, 51619, Minya, Egypt

    H. A. M. Elsherif

  5. Department of Pharmaceutical Organic Chemistry, Beni-Suef University, 62514, Beni-Suef, Egypt

    H. A. H. Elshemy, R. B. Bakr & M. A. Abdelgawad

  6. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, 11671, Riyadh, Saudi Arabia

    T. I. M. Al-Warhi

  7. Department of Pharmaceutical Analytical Chemistry, Beni-Suef University, 62514, Beni-Suef, Egypt

    M. Gamal

Authors
  1. M. M. Al-Sanea
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  2. D. G. T. Parambi
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  3. M. E. Shaker
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  4. H. A. M. Elsherif
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  5. H. A. H. Elshemy
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  6. R. B. Bakr
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  7. T. I. M. Al-Warhi
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  8. M. Gamal
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  9. M. A. Abdelgawad
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Corresponding author

Correspondence to M. A. Abdelgawad.

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Al-Sanea, M.M., Parambi, D.G.T., Shaker, M.E. et al. Design, Synthesis, and In Vitro Cytotoxic Activity of Certain 2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl]acetamide Derivatives. Russ J Org Chem 56, 514–520 (2020). https://doi.org/10.1134/S1070428020030239

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